Classical neurotransmitters and even found in same

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classical neurotransmitters and even found in same vesicles as classic neurotransmitters Adenosine is released from non-vesicular stores by: Bidirectional transporters Membrane-bound ectodiphosphohydrolase metabolizes ATP to adenosine; thus, the release of ATP can be a source of extracellular adenosine Transporters: 2 major nucleoside transporters Equilibrative Nucleoside Transporters (ENT1-4): mediate both efflux and influx Concentrative Nucleoside Transporters (CNT1-3): mediate Na+-dependent influx -chemotherapeutic (gemcitabine) and antiviral drugs (AZT) target these transporters
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