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classical neurotransmitters and even found in same vesicles as classic neurotransmitters•Adenosineis released from non-vesicular stores by:–Bidirectional transporters–Membrane-bound ectodiphosphohydrolasemetabolizes ATP to adenosine; thus, the release of ATP can be a source of extracellular adenosineTransporters:2 major nucleoside transportersEquilibrative Nucleoside Transporters (ENT1-4):mediate both efflux and influx Concentrative Nucleoside Transporters (CNT1-3):mediate Na+-dependent influx-chemotherapeutic (gemcitabine) and antiviral drugs (AZT) target these transporters
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