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The aneuploidy overall, tends to be more detrimental, but in humans, we can have some trisomic and monosimic individuals survive, but what tends to happen in that case is you don’t have the proper balance of gene expression. So if you have one too few chromosomes, you have too little gene expression and if you have too many chromosomes, you have too much gene expression and that can have really different effects depending on what that genes are. But in a lot of cases its going to interfere with cell function and even in the cases of humans, most trisomics or monosomics individuals never survive development. So its estimated that in humans, about 5'10% of all the eggs that get fertilized are going to result in an embryo that has the wrong chromosome number. And of that, approximately 50% of all miscarriages, which are spontaneous abortions, are _____. Most of these spontaneous abortions happen very early in development, so a lot of times females don’t even realize that she's pregnant at that point and they tend to not develop and get miscarried bery very early. There are some examples where we have humans that can survive some trisomies and some monosomies. Are there any chromosomes that if you had to give them up, you could? And it may not affect your survival. Which chromosomes would those be? In addition to that, besides the sex chromosomes which we have one pair of, those other 22 pairs of chromosomes are called autosomes. So are all of the autosomes the same size??? No! Some are