Nifedipine is a calcium channel blocker use in the treatment of controlling high blood pressure. Some common side effects of Nifedipine are nausea, vomiting, and diarrhea and may cause an acute liver insult. Lastly, prednisone is a corticosteroid aimed at thwarting the inflammatory sequence (Arcangelo et al., 2017). The possibility of patient HL having HCV infection, the use ofsteroid may be in use to suppress the inflamed liver and produce some comfort. Unfortunately, nifedipine increases the effect of prednisone by influencing the CYP3A4 hepatic-intestinal enzyme (Arcangelo et al., 2017). With this comorbidity, it is crucial that patient HL take prednisone with food due to the issue of the thyroid. Glucocorticoids are known to influence TSH (Younes & Younes, 2017; Haugen, 2009).Moreover, while HL is on steroid, it is possible to have a new onset of pancreatitis with presenting symptoms of nausea, vomiting, diarrhea, and pain. There is the probability that the cause of HL symptoms ranges from food poisoning (bacterial gastroenteritis), acute onset of HCV, pancreatitis, or the side effects of co-administrative drug therapy. The common symptoms point to drug-drug interactions; nevertheless, the ill-liver is unable to metabolize the patient’s prescribed drugs and is impacting the patient negatively. The prescriber will then consider reconciling the treatment order. So then, a diagnosis of an acute stage HCV infection is
plausible. Therefore in the interim, the prevention of complication from dehydration is of utmost importance for the practitioner to address immediately. Diagnostic proceduresTo appropriately diagnosis of HL condition requires sets of vital signs, a physical examination, samples of blood for (CMP, TSH, CBC, and Hepatitis RNA test), urine for (UA andC & S) analysis, culture and sensitivity; and drug screening; stool sample (looking for blood, parasites, and bacteria), ultrasound of the heart, abdomen and liver (Arcangelo et al., 2017). Comprehensive, detailed information on health history is required to assess for drug dependency,types of drug used, alcohol intake, diet, and other behavioral activities not initially reported.
- Fall '13
- Hepatitis C