100%(40)40 out of 40 people found this document helpful
This preview shows page 10 - 11 out of 11 pages.
ReferencesHuether, S. E., & McCance, K. L. (2017). Understanding pathophysiology (6th ed.). St. Louis, MO: Mosby.National Heart, Lung, and Blood Institute. (2011). Pernicious anemia.Retrieved from NURS 6501 Week 7 Response Post #1Stephanie (Rapp) Apis,You did a great job discussing anemia in your post, and I would like to expand on pernicious anemia (PA) concerning genetics. An absence of the intrinsic factor (IF) is the underlying condition in PA. A Congenital intrinsic factor (IF) deficiency is a genetic disorder that has an autosomal recessive inheritance pattern, and 20%- 30% of individuals related to a person with PA will also have PA (Huether & McCance, 2017, p. 515). Also, these relatives have a higher incidence of gastric autoantibodies, which in most cases PA results from autoimmune gastritis. Furthermore, autoimmune thyroiditis and type 1 diabetes mellitus are associated with PA, as well as other autoimmune diseases of the endocrine disorders such as Addison disease, primary hypothyroidism, Graves disease,
WEEKLY DISCUSSIONS11and myasthenia gravis (Gilbert, 2017). Finally, PA is one of the causes of vitamin B12 deficiency, and if this condition is untreated, it can cause megaloblastic anaemia and damage to the central nervous system resulting in paralysis and dementia (Gilbert, 2017).Stephanie, what foods can we educate our patients that vitamin B12 is present?ResourcesGilbert, L. (2017). Diagnosis and treatment of pernicious anemia. Practice Nurse, 47(4), 20-23. Retrieved from EBSCOhost database.Huether, S. E., McCance, K. L. (2017). Understanding pathophysiology. (6thed.). St. Louis, MO: Elsevier, Inc.