1993 brekke long 2000 functional status disorder

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Brekke et al., 1993; Brekke & Long 2000 Functional Status Disorder Variables Subjective Variables Outcome Domains in Schizophrenia Social Functioning Vocational Functioning Living Situation Positive Symptoms Negative Symptoms Self-Esteem Subjective Distress Satisfaction with Life
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Cognition in Schizophrenia: Core Feature of the Illness Present before onset of clinical symptoms Seen in unaffected first-degree relatives Relatively stable across clinical state; life span until late adulthood Low cross sectional correlations w/ psychotic symptoms Discrepancy between clinical and cognitive effects of antipsychotic meds Schizophrenia profile of deficits (w/ variation)
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Cognitive Impairment Magnitude in Schizophrenia Healthy Comparison Mean Characteristic profile in schizophrenia: maximal impairment in memory, attention, and executive function; relative preservation of old learning and visual perceptual skills. SD Units Meta-Analysis; 204 studies, 7420 patients and 5865 controls Heinrichs & Zakzanis Neuropsychology 1998
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Alzheimer’s Dementia compared with Schizophrenia Neuropsychological Deficit Scores From Heaton et al. (1994) Alzheimer’s Disease: substantial impairment in memory retention relative to schizophrenia
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Key Cognitive Domains for Schizophrenia From NIMH-MATRICS Consensus Process 1) Speed of Processing 2) Attention / Vigilance 3) Working Memory 4) Verbal Memory 5) Visual Memory 6) Reasoning and Problem Solving 7) Social Cognition
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Cognitive Domain: Verbal Learning CANARY SHOES EAGLE BLOUSE NAILS CROW BLUEBIRD SCREWDRIVER PANTS CHISEL SKIRT WRENCH Activities of daily living : remembering information from a rehabilitation program, class, vocational setting, clinic visit Definition
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