Recurrent Testicular Cancer:Treatment for recurrent testicular cancer all depends on what the cancerous cells look likeunderneath a microscope, where the cancer recurred, and other factors have to be taken into account. These treatment options include systemic chemotherapy, high-dose chemotherapy, autologous bone marrow transplants, and clinical trials are currently testing new chemotherapy drugs.
TESTICULAR CANCER7“In the past year researchers have found inherited variations in two genes called c-KIT ligand and sprouty 4 that appear to increase a man’s risk of developing testicular cancer during his life. Another study recently found that variants of three other genes, DMRT1, TERT, and ATF71P, may also increase the risk of testicular cancer” (Cancer.org 1/19/11).Currently scientists are studying the changes in DNA of testicular cancer cells to learn more about causes of this disease. These scientists hope that an improved understanding will leadto more effective treatment. There are a few gene mutations found in TC cells that have been linked to resistance to chemotherapy. with these findings scientists might be able to individualizetreatment and find new drugs that could treat the mutated genes. Being able to understand the genetic changes will help doctors decide which patients need further treatment and which patients only require surgery.New drugs and new drug combinations are being clinically tested for patients that have recurrent testicular cancer. “Stem cell transplantation is being studied as a strategy for helping men who have tumors with a poor prognosis and require more intensive chemotherapy. Also newchemotherapy combinations are being tested to see if eliminating certain drugs, replacing them with others, or lowering doses can reduce the side effects for some men without reducing the effectiveness of the treatment” (Cancer.org 1/19/11).“As more and more young men survive testicular cancer, fertility has become an increasingly important consideration. Advances in assisted reproduction methods such as in vitrofertilization have made fatherhood possible for testicular cancer survivors, even if their sperm count is extremely low. In some cases, sperm cells from a testicular biopsy specimen can be successful when other options have failed” (1/19/11).
TESTICULAR CANCER8The future for testicular cancer research looks very promising. With a little more money scientists would soon find direct causes, new treatment methods, prevention methods, and what the best treatment options are. In the next yea or so scientists will probably be uncovering what the direct cause/causes are and then the treatment for it will come up shortly after that.All the recent breakthroughs in testicular cancer research are very important. Survival rates have increased for all men that have TC, closed down the gap for causes of TC, and have given men with testicular cancer less drastic treatment options to choose from. The costs for