Some chromium compounds primarily hexavalent chromium can cause sensitization

Some chromium compounds primarily hexavalent chromium

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suscepible individuals. Some chromium compounds (primarily hexavalent chromium) can cause sensitization (chrome allergy). 4130, ER80S-BS2 and ER90S-BS3 CPH MSDS NA 918547 Version #: 01 Revision date: - Issue date: 25-March-2014 6 / 10
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Acute effects When heated, the vapors/fumes given off may cause respiratory tract irritation. High concentrations of freshly formed fumes/dusts of metal oxides can produce symptoms of metal fume fever. Local effects Elevated temperatures or mechanical action may form dust and fumes which may be irritating to the eye, mucous membranes and respiratory tract. Chronic effects Chronic inhalation of high concentrations of iron oxide fumes or dust may lead to benign pneumoconiosis (siderosis). Overexposure to manganese fumes may affect the brain and central nervous system, resulting in poor coordination, difficulty speaking, and arm or leg tremor. This condition can be irreversible Contains nickel, which can cause lung or nasal cancer. Long-term breathing of this material may cause chronic lung disease. Carcinogenicity ACGIH Carcinogens Chromium (CAS 7440-47-3) A4 Not classifiable as a human carcinogen. Hexavalent chromium compounds (CAS -) A1 Confirmed human carcinogen. Manganese (CAS 7439-96-5) A4 Not classifiable as a human carcinogen. Molybdenum (CAS 7439-98-7) A3 Confirmed animal carcinogen with unknown relevance to humans. Nickel (CAS 7440-02-0) A5 Not suspected as a human carcinogen. IARC Monographs. Overall Evaluation of Carcinogenicity Chromium (CAS 7440-47-3) 3 Not classifiable as to carcinogenicity to humans. Hexavalent chromium compounds (CAS -) 1 Carcinogenic to humans. Nickel (CAS 7440-02-0) 2B Possibly carcinogenic to humans. Nickel compounds (CAS 7440-02-0) 1 Carcinogenic to humans. US NTP Report on Carcinogens: Anticipated carcinogen Nickel (CAS 7440-02-0) Reasonably Anticipated to be a Human Carcinogen. US NTP Report on Carcinogens: Known carcinogen Hexavalent chromium compounds (CAS -) Known To Be Human Carcinogen. Nickel compounds (CAS 7440-02-0) Known To Be Human Carcinogen. US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050) Hexavalent chromium compounds (CAS -) Cancer Epidemiology Based on epidemiological studies, pre-existing pulmonary disorders may be aggravated by prolonged exposure to high concentrations of metal dust or fumes. Mutagenicity No data available. Reproductive effects This product is not reported to cause reproductive effects in humans. Manganese metal may damage the reproductive system and has shown teratogenic effects in laboratory animals. Further information During welding chromium may be oxidized and form chromium (VI) (hexavalent chromium) ions. Hexavalent chromium and its compounds are on the IARC and NTP lists as posing respiratory and sinus cancer risk. Asthma has been reported in some sensitized individuals. Skin contact may result in irritation, ulceration, sensitization, and contact dermatitis.
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