Assessment of free t4 t4 t3100 total t4 thyroxine

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Assessment of Free T4 T4 * T3/100 Total T4 (Thyroxine) Protein bound to TBG Hyper/Hypothyroidism Units: ug/dl Method: Chemiluminescence TBG – Thyroxine Binding Globulin Glycoprotein produced in liver Can be affected by drugs, disease, genetics Distinguish between thyroid dysfunction and TBG abnormalities Units: mg/dl Method: RIA Thyroid Peroxidase (TPO) Catalyzes iodination Autoimmune Ab target Method: Chemiluminescence
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Thyroid Function – Objectives Thyroid Stimulating Hormone (TSH) Most common Hypo/Hyperthyroidism Units: mU/ml Method: Chemiluminescence Sensitivity/3 rd generation – 0.01 RR: 0.40 – 5.50 mU/ml 3. Explain the clinical utility of free T4 and TSH levels and list symptoms of the following thyroid diseases: Hypothyroidism, Grave’s Disease Hypothyroidism ↑TSH, ↓FT4 Primary, Secondary or Tertiary Hashimoto’s Thyroiditis – autoimmune Goiter (swelling of the thyroid gland) Euthyroid Grave’s Disease Hyperthyroidism Most common cause of Thyrotoxicosis Autoimmune – antibodies activate TSH receptors ↑FT4, ↑T3, ↓TSH, Goiter Free T4 and TSH levels are used to detect hyper/hypothyroidism 4. Explain the relationship between TSH and Free T4.
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