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the easily distinguishable. First, the cells are unspecialized cells that are capable of renewing themselves through cell division, after long periods of inactivity. Cell division is the division of a cell into two daughter cells with the same genetic material. Second, under certain experimental conditions or physiologic conditions, they can be induced to become tissue- or organ-specific cells with unique functions. Regularly divided in order to repair worn out or damaged tissues. Human embryonic and adult stem cells each have advantages and disadvantages regarding potential use for cell-based regenerative therapies. One major difference between adult and embryonic stem cells is their different abilities in the number and type of differentiated cell types they can become. Embryonic stem cells can become all cell types of the body because they are pluripotent. Adult stem cells are thought to be limited to differentiating into different cell types of their tissue of origin.Embryonic stem cells can be grown relatively easily in culture. Adult stem cells are rare in mature tissues, so isolating these cells from an adult tissue ischallenging, and methods to expand their numbers in cell culture have not yet been worked out. This is an important distinction, as large numbers of cells are needed for stem cell replacement therapies. Scientists believe that tissues derived from embryonic and adult stem cells may differ in the likelihood of being rejected after transplantation. We don't yet know for certain whether tissues derived from embryonic stem cells would cause transplant rejection, since relatively few clinical trials have tested the safety of transplanted cells derived from hESCS.