Ans V max An enzyme will be most sensitive to changes in cellular

Ans v max an enzyme will be most sensitive to changes

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Ans: V max Section: 7.2 14 An enzyme will be most sensitive to changes in cellular substrate concentration when the concentration is . Ans: near the K M Section: 7.2 15 The type of inhibition where the product of one enzyme inhibits another enzyme that acts earlier in a metabolic pathway is considered a(an) inhibitor. Ans: feedback Section: 7.3 16 Allosteric enzymes can be identified because the plot of initial velocity, V 0 , versus substrate concentration, S, is not hyperbolic but -shaped. Ans: sigmoidal Section: 7.3 17 Negative allosteric stabilize the T-state of the enzyme. Ans: effectors Section: 7.3 2
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Chapter 7 Kinetics and Regulation Multiple-Choice Questions 18 A critical feature of the Michaelis–Menten model of enzyme catalysis is A) increasing the probability of product formation. B) shifting the reaction equilibrium. C) formation of an ES complex. D) All of the above. E) None of the above. Ans: C Section: 7.2 19 What value of [S], as a fraction of K M is required to obtain 20% V max ? [S] = A) 0.2 K M B) 0.25 K M C) 0.5 K M D) 0.75 K M E) 0.8 K M Ans: B Section: 7.2 20 Allosteric proteins: A) contain distinct regulatory sites and have multiple functional sites. B) display cooperativity. C) always consist of several identical subunits. D) A and B. E) A, B, and C. Ans: D Section: 7.3 21 Allosteric effectors alter the equilibria between: A) the ES state. B) the R and T forms of a protein. C) the forward and reverse reaction rate. E) All of the above. Ans: B Section: 7.3 22 The formula V 0 = V max [S] , indicates the relationship between [S] + K M A) the enzyme activity and the equilibrium constant. B) the rate of a catalyzed reaction and the equilibrium constant. C) enzyme activity as a function of substrate concentration. D) All of the above. E) None of the above. Ans: C Section: 7.2 23 Loss of allosteric regulation in the production of purine nucleotides results in ___________. A) excess nucleotides for DNA B) loss of RNA due to ribose phosphate synthetase C) decreased urate degradation D) loss in urate concentration E) None of the above.
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