And its true that you almost always lose weight whenever you get a traumatic

And its true that you almost always lose weight

This preview shows page 69 - 70 out of 70 pages.

And it’s true that you almost always lose weight whenever you get a traumatic injury and you lose lots of protein mass from the body. o Treatment for this large loss of protein mass: Clinicians would force a large amount of proteins and NRG into the individual, in hopes of overcoming this N loss by bringing into + balance or equilibrium a lot sooner. But it still will occur even despite seemingly adequate protein and NRG provision and you still get the N peak. B/c all the proteins you provide are just going to be oxidized and syn’d to urea. We find that it occurs in virtually all models of traumatic injury. - It s thought that over time we developed a revival mechanism by which if you got seriously hurt (cut off from your food supply), you could cannibalize your own tissue for survival. o The easiest things to catabolize are SM and skin; they also provide a huge repository. I f you’re cut off from your f ood supply you don't need mobility (can t run with a broken leg) so you just raid those tissues to free up AAs for survival proteins - Factors that affect N excretion peak: o Gender: women show less N excretion than men of the same BW. o Previous protein nutriture/ N stores: A healthy, well-nourished muscular male will excrete the most N after injury in comparison to an elderly sedentary male. (Has to do with N stores) More N stores = greater protein metabolic response to injury. On a protein-free diet you lose all N stores Po orly nourished person has greater risk for death b/c they can’t make survival proteins. So even though they don't lose much N in the urine, and don't break down much, they can’t respond to that protein metabolic response as well. An animal on a protein free diet for a week before a fractured leg will have lower N excretion compared to an animal that was well fed. o Take that same animal on a protein free diet, break the leg and then put protein back into the diet on day 1 = they’ll still excrete small amounts. o A 2 nd injury occurring soon after recovery from the 1 st (even if it's the same kind of injury) less N excretion than the first P robably b/c there’s not enough time to replete the body of its N lost during first period.
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SFLORES_4/7/2014 70 o Another thing that was found is that if you give them a long bone fracture and put them into the lab and raise the ambient temperature to the mid-80s you can completely this extra N excretion. This was repeated by a lot of different investigators Reasons unknown. But one explanation is that if you’re breaking down body proteins there’s going to be an in body temp and if you’re already in a warm environ if you continue this same protein catabolic reaction to it you would raise BT up and the animal might die due to excess heat by raising heat and the body responds by slowing down or decreasing SM catabolism by lowering the amount of N - What would you expect to find in the urine in terms of the level of 3MH pre and post injury?
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  • Spring '14
  • Knutson,MitchellD
  • NRG

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