Lecture 33 – Endocrine Physiology II

As a result heat generation also increases how does

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As a result, heat generation also increases How does it increase metabolism? Increases the rae of N/K ATPAse pump activity As aTP is hydrolyze heat is released Increased ATP hydrolysis casue high rates of fuel oxidation Increased rates of glycogenolysis and gluconeogenesis  Negative Feedback Regulation Ypothalamus secretes TSH-releasing factor (TRH) which stiultes anterior pituitary  secretion of TSH TSH then stimulates the thyroid gland to synthesize and release t3 and t4 These hormones exert negative feedback control on the hypothalamus and AP by  inhibiting the release of TRH and TSH Calcitonin is a plypeptide hormone produced hormone produced by the parafolllicular  cells in the thyroid gland It acts to reduce blood calcium, opposing the effects of parathyroid hormone (PTH) Calcitonin lowers blood Ca levels in three ways Inhibits Ca absorption by the intestines Inhibits osteoclast activity in bone Inhibits renal reabsorption of Ca increasing excretion in the urine Calcitonin receptors are found in osteoclasts and in kidney tubules nd regions of the  brains They are g-prteins which are coupled to adenylyl cyclase and to the generation of cAMP  in target cells Control of Blood Calcium PTH acts with calcitonin to regulate blood calcium PTH is a polypeptide produced bt chief cels in the parathyroid lands Acts to increase the concentration of Ca in the blood by acting upon the PTH1 receptor  (high levels in bone and kidney) and the PTH 2 receptor (high levels in the CNS,  pancreas, sex organs) Low blood Ca
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PTH released Induces osteoclasts to decompose the mineralized matrix in bone, which will release Ca  into the blood Stimulates the reabsorption of Ca by the kidney tubules Promotes the conversion of vitamin D to its active hormonal forms Vd acts directly on the intestinal epithelium to increase the rate of absorption of Ca and  increasing blood Ca
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