Cytokine treatment of cancer has proven problematic

This preview shows page 127 - 130 out of 134 pages.

78. Cytokine treatment of cancer has proven problematic because: a) cytokines can show in vivo toxicity. b) dosages are very hard to control properly. c) cytokines can regulate the production of other cytokines. d) cytokines exert effects on a large number of target cells. e) All of the above. Answer: E Section: Cancer Immunotherapy Difficulty: 1 Hint: Cytokines are great when applied to specific target cells; therapeutic use
isn t like that. 79. The use of tumor-specific T cells re-introduced to patients requires all of the following EXCEPT: a) tumor-specific cells being isolated. b) tumor-specific cells being activated in order to overcome tumor-induced anergy. c) the patient being lymphodepleted to facilitate re-introduction. d) tumor-specific cells being depleted of autoreactive clones. e) All of these steps are required. Answer: D Section: Cancer Immunotherapy Difficulty: 2 Hint: Tumors can survive by inducing anergy in responsive cells. 80. Manipulation of costimulatory signals has potential to treat tumors beca use: a) tumors that do not provide costimulation induce anergy instead. b) it is relatively easy to isolate and introduce genes to tumor cells. c) modified tumors with increased costimulatory activity can be reintroduce d to patients. d) blockage of CTLA-4 on tumors will increase T-cell activation. e) All of the above. Answer: E Section: Cancer Immunotherapy Difficulty: 2 Hint: In order to survive, tumors have to down-modulate positive costimulation, or up-regulate negative costimulation. Chapter 20 Experimental Systems and Methods 81. Polyclonal antibodies differ from monoclonal antibodies in all ways EXCE PT which of the following: a) They generally have fewer cross-reactivities. b) They are generally better for immunoprecipitation. c) They generally have lower affinity. d) They can vary from preparation to preparation. e) They differ in all of these ways. Answer: A Section: Antibody Generation Difficulty: 2 Hint: Polyclonal antibodies are produced by a variety of individual B-cells. 82. Monoclonal antibodies make excellent research tools because: a) as products of a single B cell, they all have the same specificity. b) their specificity is stable over time. c) their cross-reactivity can be well characterized. d) they are produced by transformed cells and therefore can be produced in large quantities. e) All of the above.
Answer: E Section: Antibody Generation Difficulty: 1 Hint: Monoclonals are produced by fusing B cells with immortalized cell lines, t hen selecting for individual clones.

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture