The patient has been prescribed sildenafil (Viagra). The patient wants to do everything he can to promote effectiveness of the drug. The nurse will instruct him to Selected Answer: A. avoid taking the drug with a high- fat meal. Correct Answer: A. avoid taking the drug with a high- fat meal. Response Feedback : Maximum plasma concentrations of sildenafil are reached within 30 to 120 minutes of oral dosing when taken on an empty stomach. The most frequent peak time is 60 minutes. However, when the drug is taken with a high-fat meal, absorption is slow and 60 extra minutes are needed to reach peak plasma levels. A high-fat meal reduces peak serum concentrations by 29%. Therefore, the patient should be advised to avoid high-fat meals when ingesting the drug. Avoiding a high-protein meal or drinking fluids will not help achieve quick effects from the drug. It is not advisable to increase the dosage of the drug without consulting the prescriber. Question 21 1 out of 1 points Alprostadil (Caverject), a drug used to treat erectile dysfunction, has been prescribed to a 42-year-old patient. When providing education to the patient and his wife, the nurse should inform the wife about which of the following adverse effects? Selected Answer: D. Vaginal burning Correct Answer: D. Vaginal burning Response Feedback : Vaginal burning, itching, or both can occur in the female partner of a man using intraurethral alprostadil. The nurse will advise the wife to be aware that this is a possibility. The
pharmacodynamics of alprostadil may lead to hemodynamic changes such as low blood pressure and increased heart rate in the man. However, these changes are not clinically important and would not affect the female partner. The drug is not known to decrease sexual desire in either men or women. Question 22 1 out of 1 points A nurse is explaining to a pregnant 21-year-old college student why she cannot continue to take ibuprofen (Advil) for her headaches. The nurse draws a picture depicting drug molecules crossing the placental membrane and entering into the fetal circulation. The nurse tells the patient that the main reason this happens is because Selected Answer: D. drugs compete with the hormones of pregnancy for albumin-binding sites. Correct Answer: D. drugs compete with the hormones of pregnancy for albumin-binding sites. Response Feedback : Drugs may compete with the hormones of pregnancy for albumin-binding sites, which may result in a larger amount of unbound (or free) drug in circulation, leaving the drug available to cross the placental membrane and enter the fetal circulation. A drug does not enter the fetal circulation as a direct result of increases in blood volume and heart rate or the occurrence of hemodilution. Question 23 1 out of 1 points A 20-year-old woman will soon begin taking oral contraceptives for the first time. What advice should the nurse provide to this patient?
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- Fall '13
- Pharmacology, Adverse Effect