Nonspecific sx c onjunctivits r ash desquamating a

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(Nonspecific Sx) C onjunctivits R ash (desquamating) A denopathy (cervical) S trawberry tongue H and-foot changes (edema, erythema) & Fever IVIG + Aspirin **ONLY TIME CAN GIVE ASPIRIN TO KID AFTER ILLNESS!** (Benefits outweigh risks) Buerger Dz (Thromboangiitis obliterans) Heavy smokers <40yo Ulceration, gangrene, autoamputation of fingers/toes Raynaud’s (d/t vasospasm) *white blue red* Segmental thrombosing vasculitis Smoking cessation SMALL -vessel: Arterioles, capillaries, venules Wegener granulomatosis (granulomatosis w/ polyagiitis) “C” M > F 40-60yo Granulomas in : 1) NOSE: “saddle nose ” (“ C -shaped” depression of nose) 2) SINUSES: C hronic sinusitis 3) LUNGS: C avitary granulomas 4) KIDNEYS: FN RPGN Neutrophils + FN + Granulomas C -ANCA (PR3) + (anti-proteinase 3) CXR: large nodular densities C orticosteroids + C yclophosphamide Microscopic PAN (PAN variant #1) LUNGS, KIDNEYS, SKIN w/ pauci-immune GN & Palpable Purpura - Rx/Infx NO granulomas!! Neutrophils + FN P-ANCA (MPO) + Corticosteroids + Cyclophosphamide Relapses = common Churg-Strauss (allergic granulomatosis & angiitis) syndrome (PAN variant #2) Young males LUNGS & HEART! TRIAD : 1) Granulomas 2) Asthma 3) MPO (P-ANCA) Neutrophils + FN + Eosinophils ( IgE) + Granulomas Henoch- Schonlein Purpura (HSP) MC childhood systemic vasculitis!! POST-URTI - Palpable Purple Purpura on buttocks/legs - GI pain & bleeding - Hematuria (IgA nephropathy/Berger Dz) - Arthralgias Ig A immune complex deposition Self-limited but can recur Tx w/ steroids if severe
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