6 in men or 056 in women Source Adapted from McMullin MF Reilly JT Campbell P

6 in men or 056 in women source adapted from mcmullin

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haematocrit should generally be reduced to 0.6 in men or >0.56 in women. Source: Adapted from McMullin MF, Reilly JT, Campbell P et al. (2007) Amendment to the guideline for diagnosis and investigation of polycythaemia/erythrocytosis. British Journal of Haematology, 138, 821–822. Box 4.2 Principles of management in PV and ET. • Management of cardiovascular risk factors • Low dose aspirin unless contraindicated (caution if platelet count >1000 × 109 /L) • Haematocrit control to 60 years ◦ Previous history of thrombosis ◦ Platelet count >1500 × 109 /L ◦ Additional indications for each disease are noted in the text 24 ABC of Clinical Haematology Thrombocytosis A raised platelet count (thrombocytosis) most commonly represents a reactive response to one or more of a diverse group of stimuli, such as iron deficiency, inflammation, infection or recent surgery. Additionally, thrombocytosis can be due to one of several clonal blood disorders (Box 4.3). Essential thrombocythaemia A persistent platelet count above 450 × 109 /L is the central diagnostic feature, but other reactive and clonal causes of a raised platelet count should be excluded before a diagnosis of ET can be made. The diagnosis should not be missed, however, as unlike reactive thrombocytosis, where the risk is small, ET carries a high risk of occlusive vascular events. Presentation Presentation is often incidental. Of the patients with ET, 30–
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  • Spring '18
  • Mr. kanor
  • Hematology, thrombocytosis

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