{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Anemia - Pathophysiology I - Lecture 2 (1)

Acute chest syndrome acs leading cause of death

Info iconThis preview shows pages 26–33. Sign up to view the full content.

View Full Document Right Arrow Icon
Acute chest syndrome (ACS) – Leading cause of death Pulmonary infiltrates (Unclear response to antibiotic therapy) Shortness of breath Cough Fever Chest pain Pulmonary infarction → lung damage → pulmonary arterial hypertension (PAH)
Background image of page 26

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
SICKLE CELL ANEMIA Complications Splenic injury Neurologic abnormalities Cerebral vascular occlusion (i.e. stroke) → paralysis Retina damage → blindness Infections Encapsulated organisms Streptococcus pneumoniae Haemophilus influenzae type b Klebsiella
Background image of page 27
SICKLE CELL ANEMIA – Laboratory Findings Blood work Decreased Hgb, Hct Normal MCV MCH MCHC Increased Liver function tests -bilirubin (Hyperbilirubinemia) Peripheral blood smear Normocytic Normochromic Sickled cells
Background image of page 28

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
TREATMENT GOALS – SICKLE CELL ANEMIA Goals of therapy Prevention of complications Avoid areas with high altitudes or low oxygen Adequate fluid intake Yearly eye exam Vaccinations Pneumococcal Influenza Meningococcal
Background image of page 29
CLINICAL SCENARIO #2 MM is a 21 yo AAM who presents to the ED complaining of severe left hip pain. MM describes sudden acute chest pain, shortness of breath and unproductive cough for the last 2 hours and denies trauma. PMH : Sickle cell anemia Current meds : none Medication allergies : none Immunizations : Up to date
Background image of page 30

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
CLINICAL SCENARIO #2 FH : Father - sickle cell disease, mother - sickle cell trait SH : Non-significant Vitals : BP 105/70 mmHg, HR 120 bpm, RR 22 bpm, Temp 98.9ºF, Ht 6’2”, wt 165 lbs ROS : pt crying, in pain, unable to stand up Labs : Hgb 9.1, Hct 27%, Normal MCV and MCHC
Background image of page 31
CLINICAL SCENARIO #2 What is the likely cause of MM’s abnormal laboratory findings? What signs and symptoms is MM presenting with? If a peripheral smear was performed, what would be the likely morphology of BD’s RBCs?
Background image of page 32

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Anemia – Part II Pathophysiology I Ginah Nightingale, Pharm.D., BCOP Assistant Professor Jefferson School of Pharmacy October 12, 2012
Background image of page 33
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}