A molecular biology of the cell garland science 2008

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Figure 16-10a Molecular Biology of the Cell (© Garland Science 2008) Actin polymerization G-actin = globular actin monomer F-actin = filamentous polymer of actin
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Figure 16-10b Molecular Biology of the Cell (© Garland Science 2008) Actin polymerization
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Concentration of actin determines filament formation C c is the concentration of G-actin monomers in equilibrium with actin filaments Below C c , filaments will not form Above C c , filaments form At steady state, the concentration of monomeric actin remains at the critical concentration
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Actin filaments grow faster at (+) ends than at (-) ends k on (+) >> k on (-) ATP-G-actin barbed end pointed end
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ATP-actin subunits are added faster at the (+) end than the (-) end resulting in lower critical concentration and treadmilling at steady state
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Figure 16-14a Molecular Biology of the Cell (© Garland Science 2008) Treadmilling of actin filament
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Figure 16-14b Molecular Biology of the Cell (© Garland Science 2008)
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Figure 16-15 Molecular Biology of the Cell (© Garland Science 2008)
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Actin binding proteins determine the rate of assembly and disassembly as well as the availability of G-actin for polymerization.
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Capping proteins block assembly and disassembly at filament ends
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Actin nucleation by the formin FH2 domain
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Regulation of formins
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Actin nucleation by the Arp2/3 complex WASP = Wiskott-Aldrich syndrome protein
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Regulation of Arp2/3 complex by WASP
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Shigella Cause bacillary dysentery or shigellosis The source in each case is unwashed hands Human is the only “reservoir” Uses power of actin polymerization for intracellular movement Microbiol. Mol. Biol. Rev. 65:595-626
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