Ranges from mild few flakes on scalp to severe

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- Ranges from mild (few flakes on scalp) - To Severe (heavily laden with dandruff flakes) Incidence: - Appears in puberty when skin activities are altered. - Decline in advancing years. - Disappear in old ages . Treatment: 1)) keratolytics: - Resorcinol, sulfur, salicylic acid A) Resorcinol:      Has irritant effect on the skin. B) Sulfur:       Increases sloughing of the cell. C) Salicylic acid:      Decreases PH of skin, so increases keratin hydration, facilitate cells  removal (( best keratolytic in O/W emulsion base)) 2)) Soaps and detergents: - Make subsequent sloughing of keratin to be in smaller, less visible subunits 3)) Cytotoxic agents: (Selenium sulphide – Zinc pyrithione) - Increases time necessary for epidermal turnover. Disadvantages: - Cause burning sensation of skin under finger nails. - Selenium sulphide may cause conjunctivitis. - Zinc pyrithione is bound to external layer of skin, doesn’t penetrate dermal region.
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- These agents shouldn’t be used ao broken or braded skin. Factors affecting adsorption of cytotoxics on skin scalp: 1) ↑ conc of cytotoxics 2) ↑ contact time 3) ↑ temp 4))Dispersing agents: Mechanism: disperse the scales into smaller subunits. Ex: Detergents: SLS Coal tar Quaternary ammonium compounds
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