There are two major types of bacteria in digestive tract that may play a role in
weight control - the more
Bacteroidetes
you have, the more likely you are to be
lean
, the more
Firmicutes
you have, the more likely you are to be
fat.
•
Rodent studies have confirmed this
•
These studies also showed that if the mice get the bacteria from an overweight
mouse they would only become overweight if they were fed an inadequate diet,
diet matters!!
-
= bacteria has a role to play ONLY in the presence of a poor diet
-
Average American consumes half a litre of soft drinks a day (200 extra calories) - cutting this
out can lead to a loss of two pounds a month
Topic 9: DIET AND DISEASE
Lesson 1: Diet and cancer
VIDEO 1
CAUSES OF CANCER :
-
Environment: 90%
•
Diet and obesity: 30-35%
-
Cancer is most frequent among those branches of the human race where
carnivorous habits prevails
•
Tobacco: 25-30%
•
Infections: 15-20%
•
Radiation: 5-10%
•
Pollution: 3-5%
•
Alcohol/sexual: 3-5%
-
Genetics: 5-10%
Study: environmental and heritable factors in causation of cancer (2000,
Scandinavia)
-
45,000 pairs of twins studied
-
10,000 cancers occurred
-
Some cancers showed heritable factors
•
Stomach cancer
-
Environmental — Shared = 10% // Environmental — Non shared = 62%
22 of 66

-
Heritable = 28%
•
Cervical cancer
-
Environmental: high
-
Heritable: low
•
Absolute risks (risks are averaged over a range)
-
Monozygotic twins (identical): 15%
-
Dizygotic twins (fraternal): 6%
•
Conclusion:
-
Unmistakable heredity: 1%
-
Major component heredity: 15%
Another study on Norwegian Twins: heritability and familial risk of cancer (2013)
•
Monozygotic and dizygotic pairs: 133,689
•
Prostate cancer heritability (2013)= 58%, whereas prior study (2000) = 42%
•
Other cancer rates lower and varied
-
CONCLUSION : even with twins, environmental factors strongly
dominate
VIDEO 2
-
The term cancer comes from the Latin for "crab", because originally tumours and their blood
vessels seemed to look like crabs with all of their legs
-
More than
half a million
people in the United States die of cancer every year
•
About 1,500 Americans a day
-
Mortality
of cancer is decreasing,
rate of cancer has increased
a bit because of increased
ways of
detecting
it, but overall there is
no cancer epidemic
•
Some cancers are falling and some are increasing, but the general cancer rate is
about the same
•
Varies with location (environment and diets)
•
Childhood cancer seems to be increasing, but we don’t know why
-
Breast cancer
rates decreased when estrogen supplements stopped being given to
menopausal women — these estrogen supplements were a main cause
-
There are very significant variations of
cancer rates
around the world
•
In some areas, some cancers are more frequent than others
•
suggests that environment influences the development of cancer
•
When people migrate from one country to the other, they tend to take on the
cancer patterns of their new domicile
23 of 66

-
30-40% of cancers in the world, some 4 million cases a year,
can be prevented by paying
attention to environmental factors such a
diet
•
Five or more servings of
fruit
a day lowered the risk of
prostate cancer
by
50%
•
2,000 mg a day of
calcium


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- Spring '11
- Multiple
- Nutrition