Enabling the initiation of the action effect sequence

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enabling the initiation of the action- effect sequence Not so stable that it cannot be reversed Selectivity, specificity and reversibility are due to the synchronous operation of a number of chemical bonds-not a single bond
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Drug-Receptor Interactions Forces to hold it to receptor=chemical bonds - Ionic bonds: electrostatic attraction; transfer of electrons (- charged molecule binds to a + charged molecule & vice versa); rapid & relatively strong bond; can occur across distances; holds drug to receptor - Covalent bonds: sharing a pair of electrons; very strong bond (20 times stronger than ionic bond); accounts for stability of most organic molecules - Hydrogen bond: type of ionic bond with hydrogen (+ charged); weak bond but if multiple hydrogen bonds are formed high stability - Van der Waals forces: weak attractive forces between 2 neutral atoms; operate in close range; “final notches in key that open the door” Ionic bond Covalent bond Hydrogen bonds
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