These are classified as stress induced gastritis or

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THESE ARE CLASSIFIED AS STRESS INDUCED GASTRITIS OR ULCERS. THE LESION IS MOST COMMONLY SEEN IN THE ACID PRODUCING (FUNDUS AND BODY) PORTIONS OF THE STOMACH. 246
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STRESS ULCER SEEN IN BURNS ARE CALLED  CURLING ULCER. STRESS ULCER SEEN IN HEAD INJURY ARE CALLED  CUSHING’S ULCER. 247
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STRESS ULCERS SEEN IN BURNS ARE - (PGIDEC 2000) A) CURLING’ ULCER B) CUSHING’S ULCER C) MELENEY’S ULCER D) RODENT ULCER A 248
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Q- HYPERGASTRINEMIA HYPERGASTRINEMIA WITH HYPOCHLORHYDRIA IS SEEN IN - A) ZOLLINGER ELLISON SYNDROME (AI 02) B) VIPOMA C) PENICIOUS ANEMIA D) GLUCAGONOMA 249
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GASTRIN IS PRODUCED BY G CELLS OF THE ANTRUM. IT ACTS ON THE PARIETAL CELLS OF THE STOMACH CAUSING ACID RELEASE. THE GASTRIC ACID RELEASED INHIBITS FURTHER RELEASE OF GASTRIN. THIS EFFECT OF ACID IS THE BASIS OF NEGATIVE FEED BACK. 250
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IN PERNICIOUS ANEMIA THE ACID SECRETING CELLS PARIETAL CELLS OF THE STOMACH ARE DAMAGED THEREFORE THE ACID SECRETION IS REDUCED INSPITE OF NORMAL GASTRIN LEVEL. A DECREASE IN ACID SECRETION WILL SUBSEQUENTLY LEAD TO FAILURE OF THE FEEDBACK INHIBITORY PATHWAY, RESULTING IN HYPERGASTRINEMIA. GASTRIN LEVELS WILL THUS BE HIGH IN PATIENTS WITH PERNICIOUS ANEMIA. 251
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CAUSES OF HYPERGASTRINEMIA :- G CELL HYPERPLASIA . GASTRIC OUTLET OBSTRUCTION . RENAL INSUFFICIENCY . MASSIVE SMALL BOWEL OBSTRUCTION 252
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HYPERGASTRINEMIA WITH HYPOCHLORHYDRIA IS SEEN IN - A) ZOLLINGER ELLISON SYNDROME (AI 02) B) VIPOMA C) PENICIOUS ANEMIA D) GLUCAGONOMA C 253
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Q-ZES Q) THE TRIAD ORIGINALLY DESCRIBED BY ZOLLINGER ELLISON SYNDROME IS CHARACTERIZED BY - (AI 02) A) PEPTIC ULCERATION, GASTRIC HYPERSECRETION, NON BETA CELL TUMOUR B) PEPTIC ULCERATION, GASTRIC HYPERSECRETION, BETA CELL TUMOUR C) PEPTIC ULCERATION, ACHLORHYDRIA, NON BETA CELL TUMOUR 254
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SEVERE PEPTIC ULCER DISEASE SECONDARY TO GASTRIC ACID HYPERSECRETION DUE TO UNREGULATED GASTRIN RELEASE FROM A NON BETA CELL ENDOCRINE TUMOUR (GASTRINOMA), DEFINES THE COMPONENTS OF ZOLLINGER ELLISON SYNDROME. 255
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PATHOPHYSIOLOGY OF ZOLLINGER ELLISON SYNDROME:- THE DRIVING FORCE RESPONSIBLE FOR CLINICAL MANIFESTATIONS OF ZOLLINGER ELLISON SYNDROME IS HYPERGASTRINEMIA ORIGINATING FROM GASTRINOMA (AUTONOMUS NEOPLASM, NON BETA CELL NEOPLASM) 256
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257
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OVER 80% OF THESE TUMOURS ARE SEEN IN GASTRINOMA TRIANGLE (TRIANGLE FORMED BETWEEN DUODENUM AND PANCREAS ) MOST OF THEM ARE SEEN IN THE HEAD OF PANCREAS. ABOUT 2/3RD OF THESE TUMOURS ARE MALIGNANT. ABOUT ONE HALF OF THESE TUMOURS ARE MULTIPLE. ABOUT ONE FOURTH OF THE PATIENTS HAVE MULTIPLE ENDOCRINE NEOPLASIA (MEN I) SYNDROME WITH TUMOURS OF PARATHYROID, PITUITARY AND PANCREATIC ISLETS BEING PRESENT. 258
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Q-ZES THE TRIAD ORIGINALLY DESCRIBED BY ZOLLINGER ELLISON SYNDROME IS CHARACTERIZED BY - (A 102) A) PEPTIC ULCERATION, GASTRIC HYPERSECRETION, NON BETA CELL TUMOUR B) PEPTIC ULCERATION, GASTRIC HYPERSECRETION, BETA CELL TUMOUR C) PEPTIC ULCERATION, ACHLORHYDRIA, NON BETA CELL TUMOUR A 259
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Q-DIAGNOSIS MOST IMPORTANT INVESTIGATION FOR DIAGNOSIS OF ZOLLINGER ELLISON-SYNDROME IS - (AI 99)
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  • Winter '16
  • jean grey
  • chronic hepatitis, chronic liver failure

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