KARA - Immunology Exam 4 - Chapter 7 & 8.docx

Recruitment involves secondary lymphoid tissues

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Recruitment involves secondary lymphoid tissues. Antigen is brought in from outlying tissues via lymph . Antigen encounters the T cells brought in via blood . 1. Examination of the activation of naïve T cells effector T cells by professional APC (P-APC) within lymphoid tissues Dendritic cell 2. Interaction of a naïve T cell with antigen presented by cells other than P-APCs leads to inactivation rather than activation of T cells
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Slides 61-62 | Dendritic cells carry antigens from sites of infection Slide 61 ↓ | The immune system does not initiate the adaptive immune response wherever a pathogen creates a site of infection . The immune system captures the pathogen and takes it to the secondary lymphoid tissues. Mediated by dendritic cells (migratory) Process is same for infections in peripheral tissues, mucosal surfaces and blood Dendritic cells are sentinels in all body tissues Activated with pathogen uptake and antigen processing and presentation by MHC I and II molecules. Slide 62 ↓ | Dendritic cells – Major function is the triggering T-cell responses highly specialized and effective. Dendritic cells are migratory cells and have highest concentration of B7 carry load of antigen from infection site nearest secondary lymphoid tissues. Slide 63-64 | Dendritic cells take up antigen, migrate to lymphoid organs, and present foreign antigens to naïve T cells Slide 63 ↓ | Movement of dendritic cell from site of infection in the periphery to a secondary lymphoid organ causes changes in the dendritic cell’s surface molecules, functions and morphology. In tissues , dendritic are active in the capture, uptake and processing of antigen – called immature dendritic cells . In secondary lymphoid tissues, dendritic cells gain the capacity to interact with T cells – called mature or activated dendritic cells (no longer phagocytic). Mature dendritic cells have finger-like processes called dendrites that contact T cells in the cortex of lymph node . Slide 64 ↓ | Wound in the skin Langerhans’ cells (immature dendritic cells) take up the antigen and migrate to a nearby lymph node. Settle in the T-cell areas.
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Differentiate into mature dendritic cells. 1. Dendritic cells take up bacterial antigens in the skin and then move to enter a draining lymphatic vessel 2. Dendritic cells bearing antigen enter the draining lymph node, where they settle in the T-cell areas Slide 65 | Skin & peripheral tissue infection = T cell response in draining lymph nodes. Blood infections = antigen enter the spleen Respiratory mucosa infection = tonsils or other bronchial-associated lymphoid tissue (BALT).
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  • Winter '17
  • T Cells, T Cell, development of T cells

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