o Persistent diarrhea and failure to grow in children o Unexplained weight loss

O persistent diarrhea and failure to grow in children

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o Persistent diarrhea and failure to grow in children. o Unexplained weight loss in adults. - Celiac patients sometimes show rashes but only way to confirm celiac disease is to by endoscopic biopsy. o Need to use a scope, go into duodenum, take a sample and look under microscope and they will tell if villi have fused together. - Also, blood tests possible, they will test for antibodies. (Gliadin will be seemed as an invader and produce antibodies) but only 50% of patients show damaged villi upon biopsy. - ANTI-tTG --> another test, better results upon biopsy. - Have to stay away from gluten, anything from rice, corn, soy is fine. These do not contain gluten. A lot of companies prepare gluten free products. - Rice Krispies, rice not made from gluten but some additives might have gluten so it is saying no gluten from that - Incidence: approx. 1 in 100 people affected - It may be linked with non- Hodgkin’s lymphoma. Celiac patients have a higher risk in getting this disease, doesn't mean they will get it but it is a risk factor. - Celiac can lead to osteoporosis, it can cause headache, behavioral problems, neurological problems, theories it is connected to autism. - Silent Celiac Disease o 1/200 people have it. o They can eat gluten without risk. o But they have a positive blood test and biopsy. Should they be put on gluten free diet?? o Studies suggest that they may develop celiac disease later on. - Latence Celiac Disease o Positive blood test but endoscopy is negative. o Negative biopsy. o People say they should not go on a gluten free diet but it said to be usually "watchful waiting". - Non-Celiac Gluten Sensitivity o May affect 6-10% of the population, 6 times as much as celiac disease. o No positive blood test or blood biopsy. o But if they go off gluten, they feel better. o These are people who have other problems, headaches, rashes. o No risk going on a gluten free diet except that not so easy to follow.
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TOMAZOS WINTER 2020 CHEM 181 41 Lesson 2: Adverse Food Reactions II Video 1 - Classical Food Allergies: - Swelling, nausea, cramping, diarrhea, eczema, itching, vomiting, flatulence, asthma, rhinitis, - Anaphylaxis --> collapse of circulatory system and can quickly lead to death. - So, what happens in an allergy? o Body's immune system makes a mistake and attacks a foreign substance and think it’s bad when it's not. o It produces antibodies, those upon meeting the allergen next time will engulf it and try to digest. The fight between antibody and allergen. o Body attempts to get rid of allergen. - Foods like milk, eggs, nuts, shellfish, fish (just because allergic to shellfish does not mean you will be allergic to fish) ---> most allergenic foods. - They will give rise to antibodies upon exposure, nobody is never allergic upon first exposure because first exposure triggers antibody formation. Second/subsequent exposure you get antibody allergen reaction that is what manifests symptoms of allergies.
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