oPersistent diarrhea and failure to grow in children. oUnexplained weight loss in adults. -Celiac patients sometimes show rashes but only way to confirm celiac disease is to by endoscopic biopsy. oNeed to use a scope, go into duodenum, take a sample and look under microscope and they will tell if villi have fused together. -Also, blood tests possible, they will test for antibodies. (Gliadin will be seemed as an invader and produce antibodies) but only 50% of patients show damaged villi upon biopsy. -ANTI-tTG --> another test, better results upon biopsy. -Have to stay away from gluten, anything from rice, corn, soy is fine. These do not contain gluten. A lot of companies prepare gluten free products. -Rice Krispies, rice not made from gluten but some additives might have gluten so it is saying no gluten from that -Incidence: approx. 1 in 100 people affected -It may be linked with non-Hodgkin’s lymphoma. Celiac patients have a higher risk ingetting this disease, doesn't mean they will get it but it is a risk factor. -Celiac can lead to osteoporosis, it can cause headache, behavioral problems, neurological problems, theories it is connected to autism. -Silent Celiac Disease o1/200 people have it. oThey can eat gluten without risk. oBut they have a positive blood test and biopsy. Should they be put on gluten free diet?? oStudies suggest that they may develop celiac disease later on. -Latence Celiac Disease oPositive blood test but endoscopy is negative. oNegative biopsy. oPeople say they should not go on a gluten free diet but it said to be usually "watchful waiting". -Non-Celiac Gluten Sensitivity oMay affect 6-10% of the population, 6 times as much as celiac disease. oNo positive blood test or blood biopsy. oBut if they go off gluten, they feel better. oThese are people who have other problems, headaches, rashes. oNo risk going on a gluten free diet except that not so easy to follow.
TOMAZOS WINTER 2020 CHEM 181 41 Lesson 2: Adverse Food Reactions II Video 1 -Classical Food Allergies: -Swelling, nausea, cramping, diarrhea, eczema, itching, vomiting, flatulence, asthma, rhinitis,-Anaphylaxis --> collapse of circulatory system and can quickly lead to death. -So, what happens in an allergy? oBody's immune system makes a mistake and attacks a foreign substance and think it’s bad when it's not.oIt produces antibodies, those upon meeting the allergen next time will engulf it and try to digest. The fight between antibody and allergen. oBody attempts to get rid of allergen. -Foods like milk, eggs, nuts, shellfish, fish (just because allergic to shellfish does not mean you will be allergic to fish) ---> most allergenic foods. -They will give rise to antibodies upon exposure, nobody is never allergic upon first exposure because first exposure triggers antibody formation. Second/subsequent exposure you get antibody allergen reaction that is what manifests symptoms of allergies.