compounds found in plants o Antioxidant properties o Polyphenol o Have anticancer properties o Research done by Dr. Lilian Thompson at UofT Investigates breast cancer Gave patients flax seeds (high lignin content) in muffins Muffins contain ~25g of flaxseed Results: Demonstrated potential of dietary modification with flaxseed (lignans), in reducing tumor growth in patients with breast cancer COMPARABLE to the effects seen with preoperative tamoxifen ° ° Prostate Cancer & Diet Prostate cancer Downloaded by Riviera Dresden ([email protected]) lOMoARcPSD|3695286
o Most commonly seen cancer in men o ~20K cases diagnosed every year in Canada o Most men diagnosed tend to die WITH it, not BECAUSE of it Slow-growing cancer Lycopene o Red pigment o Found in tomatoes(esp.), pink grapefruit, watermelon o Tomatoes linked to prostate cancer? Wayne State lycopene trial- human intervention study Only 15 patients Lypocene 2x daily for 3 weeks before prostate surgery Compared to patients receiving placebo Result: tumors smaller & showed reduced malignancy Health Professionals Follow-up Study-cohort study 50K men Compared with men consuming less than 1.5 servings a week of lycopene products Those eating more than 10 servings had 35% risk Tomatoes are good for you, but are not miracles Allicin o Found in garlic (chopped/cooked) o Reduces risk of certain cancers o Many Mediterranean countries have lower risk of stomach cancer (associated with garlic being used frequently in cooking) o Plausible because in vitro, allicin has been linked with chemical rxns that carcinogenesis Curcumin o Found in turmeric o Investigating in terms of cancer & Alzheimer’s disease o In India, Alzheimer’s (lower than NA) Diagnostic techniques questionable They eat lots of curry (which contains curcumin) o Many studies suggest it’s a good idea to use spices in cooking o No evidence that taking special curcumin tablets is beneficial Brassica vegetables o BROCCOLI Downloaded by Riviera Dresden ([email protected]) lOMoARcPSD|3695286
“Nature’s cancer fighter” Contains glucoraphanin When cooked/chewed, breaks down & produces sulphoraphane Sulphoraphane induces formation of phase-2 enzymes Phase-2 enzymes: responsible for tying up potential toxic materials (ex. Carcinogens) & ferrying them out of the body Ample clinical evidence that [phase-2 enzymes] is linked with risk of cancer Scientific studies done with brassica/ cruciferous vegetables (mustard family, includes broccoli) Animal feeding trial: rats fed sulphoraphane after exposure to known carcinogen (dimethyl benzathracene) 70% of control rats developed cancer b/c of carcinogen 2X the # of animals that were fed broccoli extract BroccoSprouts (young broccoli just sprouting) has ~50x as much sulphoraphane as adult broccoli But, does not keep well In vitro studies: sulphoraphane is added to cultured human cancer cells and is determined to offer protection against cancer o Cabbage Contains indole-3-carbinol Anticarcinogen ° °
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