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Lecture3_Gene_Regulate 1.49.03 AM

Repressors can be under the control of other

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Repressors can be under the control of other molecules (i.e. inducers) that dictate when repressor is bound and not.
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Activators: The Cartoon Activators: The Cartoon Activator molecules enhance the action of RNA polymerase. Activators can be under the control of other molecules (i.e. inducers) that dictate when activator is bound and not. Activators “RECRUIT” the polymerase. Adhesive interaction between RNAP and activator
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All Together Now: The Lac Operon All Together Now: The Lac Operon Our goal: mathematize the story told by all of these cartoons. In particular, compute the probability of RNAP binding as a function of concentration of all the other molecular actors.
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Structures of the Molecular Actors Structures of the Molecular Actors in the Lac Drama in the Lac Drama (Beautiful work of David Goodsell) RNAP+DNA+mRNA Lac Repressor CRP and DNA Products of the Lac Operon
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) ( ) 0 ( (L) Repression bound bound L p L p = = Repression level depends upon the spacing of the operators. Once again, we assert that the dynamical definition can be replaced by an equilibrium description. Repression in the Lac Operon: the Role of Looping
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