Which of the following would be a proper expression

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3. Which of the following would be a proper expression for the dissociation constant associated with ligand (L) binding to receptor (R)? A) Kd [R][1,] [R - L] [L] B) Ka = C) K d [R •L] [R][L] [R] - F[R • L] 4. Which of the following amino acids is (are) capable of participating in acid/base catalysis? A) Thr B) Arg C) Met D) Asp E) Gln F) none of the above G) all of the above 5. A ligand that binds to a receptor to elicit a biological effect is known as a(n) A) antagonist B) agonist C) protagonist D) inverse agonist 6. Which of the conditions below represents a steady state? B) d[ES]ldt = 0 C) d[P]ldt = 0 D) d[S]ldt = d[P]ldt Version 3 Page 1
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7. Due to the hydrophobicity of the lipid bilayer, small ions like K+ are never able to leave the cell by simple diffusion. A) True B) False 8. A molecule moves across a membrane from a lower to a higher concentration with the aid of a membrane protein. This process is known as: A) chemiosmotic coupling B) diffusion C) active transport D) facilitated transport 9. Which of the following is NOT a function of lipid molecules? 10. Can an enzyme that obeys Michaelis-Menten kinetics be influenced by allosteric effectors? A) Yes B) No 11. Which type of secondary structure present in integral membrane proteins is readily detectable in the primary structure? A) membrane-spanning a helix B) membrane-spanning (3 sheet 12. What is the one defining feature of lipids? A) They all contain flexible hydrocarbon chains. D) They all contain large polar head groups. B) They are all a type of fatty acid. E) They all can form polymers. C) They are all primarily hydrophobic. 13. Ion channels can open in response to which of the following 14. What type of protein secondary structure predominates in G-protein coupled receptors? A) a helices B) (3 sheets C) B-type helices D) None predominates 15. Chymotrypsin catalyzes peptide bond cleavage after large nonpolar residues and will not hydrolyze any other type of bond. A) True B) False 16. In which of the following mechanisms is the first product released before the second substrate binds? A) random sequential B) ordered sequential C) ping pong Section II: 66 points (2 points each) 17. Which of the following is FALSE regarding the catalytic mechanism of chymotrypsin? A) Ser195 functions as a covalent catalyst B) His57 functions as a base catalyst C) His57 functions as an acid catalyst D) The function of the oxyanion hole is best explained by the induced fit model of substrate binding. E) Asp 102 stabilizes the transition state through low-barrier H-bonds.
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