9 give a general description of the genetic makeup

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9. Give a general description of the genetic makeup and structure of the Herpes family of viruses. 10. What is one main difference between those classified as alpha family and those classified as beta or gamma? 11. What are the typical clinical manifestations (if any) of infection by HSV1? HSV2? 12. What are some differences in the epidemiology between HSV1 and HSV2? (prevalence, typical age at infection) What are some similarities? 13. What are the 4 stages of infection by HSV infection? 14. What is unusual about the budding of HSV particles? 15. What are some of the mechanisms used by this family of viruses to evade the immune response? 16. What does it mean for a virus to enter latency? 17. Why does reoccurrence of symptoms occur in some people and not others? 18. What is meant by the term tissue tropism? What tissue(s) are HSV1 and HSV2 trophic for? 19. What is the mechanism of action of acyclovir?
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20. Describe the diseases caused by the other Herpes virus family members. What did we learn about varicella‐zoster, CMV and Epstein‐Barr? 21. What are some of the general characteristics of HPV? 22. Describe the relationship between HPV and cervical cancer. How was it discovered? 23. What role is integration of the viral DNA into the host genome thought to play in the development of cancer?
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Lecture 9 Guide 1. What are the general characteristics of retroviruses? 2. What are the two major classes of retroviruses and an example of each? 3. Describe the structure of the HIV virus. 4. Describe the replication cycle of HIV. 5. What are the typical proteins found in a retrovirus and what are the functions of the proteins? 6. When was HIV discovered? What was the epidemiology at that point and how has it changed? 7. What types of cells are targeted by HIV? 8. What are the clinical manifestations of HIV infection? Of AIDS? 9. What are some of the antiviral therapies that are used to treat HIV infection? Why are they often used in combination treatments? 10. What are the characteristics of hepatitis viruses? 11. What are the differences in the pathogenesis of the viruses? Which is typically cleared and which is most often chronic? 12. Why is the presence of IgM antibody important in diagnosis of hepatits virus? 13. Describe the HBV genome. What makes it unique? 14. Why are mutation rates low in HBV? 15. What is the current theory on why HBV and HCV lead to HCC? 16. What is unique about HDV infections? 17. Why do you see high mutation rates in HCV? 18. Why is it important to genotype the virus in HCV infections? 19. What are arboviruses? 20. What are three ways that arboviruses are maintained in a population?
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