Lecture_2-Basic_Pharmacological_Principles

Interpreting dose effect curves dose response curves

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Interpreting dose-effect curves Dose-response curves can also provide a measure of potency ; the dose needed to produce a particular effect of a given intensity Potency also varies inversely with the magnitude of dose depends on inherent ability of the drug to bind to a receptor (affinity=Kd) Depends on factors regulating how much drug reaches the site of action Comparative expression of drug activity at a particular site ( relative to a standard of reference )
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Interpreting dose-effect curves: Full vs. partial agonists Partial agonists elicit a biological response upon binding but the magnitude of the response ( efficacy ) is reduced NOTE: efficacy is independent of affinity (in this example, the partial agonist has a much lower Bmax than the full agonist, but the Kd is lower than the full agonist)
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