Exclusion criteria patients who consumed tobacco in

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Exclusion criteria Patients who consumed tobacco in any form Patients who had undergone periodontal therapy in the last 6 months Patients who had received antibiotic therapy in the previous 3 months Patients who were taking or had consumed vitamin supplements, anti-inflammatory agents, or statins in the previous 3 months. Patients with any systemic disorder affecting periodontal health Patients with infectious conditions other than periodontitis Regular users of mouthwash Chronic alcoholics. Study design Informed written consent was obtained from all the subjects before participating in the study. All study subjects underwent an oral examination, and the below-stated indices were recorded by a single examiner. Baseline periodontal assessment included as follows: Plaque index (PI) [17] Gingival index (GI) [18] PPD Relative attachment level (RAL). [19] In each recruited patient, teeth with PPD of ≥5 mm were allotted to either. Group A - ( n = 50): Control sites: Treated with SRP only or Group B - ( n = 50): Test sites: Treated with SRP + hyaluronan gel 0.8%. Full mouth SRP was performed for all the subjects. The experimental sites were gently dried using an air syringe and isolated with cotton rolls. This was followed by subgingival administration of 0.2 ml 0.8% HA gel into selected sites following SRP [Figure 1b]. The 0.8% HA gel was in the form of preloaded 1 ml syringes with a blunt cannula [Downloaded free from on Friday, September 15, 2017, IP: 36.79.172.174]
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Shah, et al .: Hyaluronan as local drug delivery Journal of Indian Society of Periodontology 3 different time intervals during follow-up showed that there was a statistically significant reduction in the PI scores at each follow-up as compared to baseline. However, there was no significant difference found between 4 weeks and 12 weeks follow-up. These findings were true for both the test and the control group [Table 2 and Graph 2]. Gingival index Inter-group comparisons of GI at each follow-up carried out by t -test revealed no significant difference between the groups at any stage during the follow-up as seen in Table 3 and Graph 3. Comparison at different time intervals during follow-up done showed that there was a statistically significant reduction in the GI scores at each follow-up as compared to baseline. However, there was no significant difference found between 4 weeks and 12 weeks follow-up. These findings were true for both the test and the control group [Table 4 and Graph 4]. Probing pocket depth There was no statistical difference found at baseline between the test and the control group. However, there was significantly significant reduction in the probing depths in test group as compared to the control group at both, 4 weeks ( P = 0.044) and 12 weeks ( P = 0.041) recall as shown in Table 5 and Graph 5. Comparison at different time intervals during follow-up showed a statistically significant reduction in the probing depths at each follow-up as compared to baseline.
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  • Fall '19
  • Statistical significance, SRP, Periodontitis, Hyaluronan

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