After puberty the systolic pressure rises to adult

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sharply during the first 6 weeks. After puberty, the systolic pressure rises to adult levels. Adolescence growth spurt- ↑ in BP and ↓ in HR. Arteries and and veins lengthen to keep pace with growth. Older adults arterial stiffening ↑ in BP upon standing- orthostatic hypotension may contribute to falls. ↑ in the work load of the myocardium ↓ in CO by 30-40% Impaired perfusion- result in ↓ CO Central perfusion can result from: ↑ SVR requires the heart to increase contractile force and/or increase HR to maintain adequate CO. a sustained SVR eventually leads to insufficient central perfusion attributed to vasoconstriction of the arteries or increased viscosity of the blood When central perfusion is impaired, clinical manifestations are systemic the entire body is affected Significant reduction in central perfusion results in Shock Shock- occurs when blood supply to tissues is impaired because of inadequate CO, significant blood loss, or vasodilation throughout the body( dilation of blood vessels, which decreases BP) Interference with Tissue perfusion-reduces blood flow through capillaries into the interstitial spaces allowing delivery of oxygen, fluid, and nutrients to cells.
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