Lecture_8

20 how hiv kills the cd4 t cells hiv replication

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20 How HIV kills the CD4+ T cells • HIV replication depletes T cell’s resources • Virus budding causes cellular leakage • Syncytium formation • HIV infected T cells expressing HIV Ag will be attacked and destroyed by normal Tc
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21 How is HIV Transmitted? • HIV is stopped by innate defenses • Direct exchange of body Fuids - Sexual intercourse - Blood to blood contact - Mother to fetus - cannot penetrate unbroken skin
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22 Macrophage Dendritic cell • Both are APC • Abundant in tissues that are in contact with the external environment • Express CD4 on their surface
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23 Schematic fgure oF a lymph node
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24 Dendritic Cells in Lymph Nodes Lymph Node Macs From Tissues Ab and activated Tc cells To Blood Follicle Dendritic Cells
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25 In the lymph nodes, follicular dendritic cells spread HIV to T cells
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26 HIV adsorption
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27 HIV Adsorption
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28 HIV Co-Receptors (Fig. 2.12, Text) T Lymphocyte gp41 gp41 CD4 CXCR4 gp120
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29 HIV Co-Receptors on T cells vs Macrophages/Dendritic Cells CD4+ T Lymphocyte Macrophage/Dendritic Cells
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Function of Co-Receptors • CXCR4 and CCR5 proteins are chemokine receptors • Chemokines: - Chemical messengers
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20 How HIV kills the CD4 T cells HIV replication depletes T...

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