20 how hiv kills the cd4 t cells hiv replication

Info icon This preview shows pages 8–20. Sign up to view the full content.

20 How HIV kills the CD4+ T cells • HIV replication depletes T cell’s resources • Virus budding causes cellular leakage • Syncytium formation • HIV infected T cells expressing HIV Ag will be attacked and destroyed by normal Tc
Image of page 8

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

21 How is HIV Transmitted? • HIV is stopped by innate defenses • Direct exchange of body fluids - Sexual intercourse - Blood to blood contact - Mother to fetus - cannot penetrate unbroken skin
Image of page 9
22 Macrophage Dendritic cell • Both are APC • Abundant in tissues that are in contact with the external environment • Express CD4 on their surface
Image of page 10

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

23 Schematic figure of a lymph node
Image of page 11
24 Dendritic Cells in Lymph Nodes Lymph Node Macs From Tissues Ab and activated Tc cells To Blood Follicle Dendritic Cells
Image of page 12

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

25 In the lymph nodes, follicular dendritic cells spread HIV to T cells
Image of page 13
26 HIV adsorption
Image of page 14

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

27 HIV Adsorption
Image of page 15
28 HIV Co-Receptors (Fig. 2.12, Text) T Lymphocyte gp41 gp41 CD4 CXCR4 gp120
Image of page 16

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

29 HIV Co-Receptors on T cells vs Macrophages/Dendritic Cells CD4+ T Lymphocyte Macrophage/Dendritic Cells
Image of page 17
30 Function of Co-Receptors • CXCR4 and CCR5 proteins are chemokine receptors • Chemokines: - Chemical messengers - Small proteins similar to cytokines - Produced by macrophages during inflammatory reaction - Attract T lymphocytes to site of infection
Image of page 18

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

31 Importance of chemokine co-receptor in HIV transmission
Image of page 19
Image of page 20
This is the end of the preview. Sign up to access the rest of the document.
  • Winter '08
  • Staff
  • cells spread HIV, hiv co-receptors

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern