Acetyl-CoA carboxylase 2-:- mutant mice are protected against fatty liver under high-fat, high-carb

Proc natl acad sci usa 103 85528557 16 oh w abu

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accumulation without affecting glucose homeostasis. Proc. Natl. Acad. Sci. U.S.A. 103, 8552–8557 16. Oh, W., Abu-Elheiga, L., Kordari, P., Gu, Z., Shaikenov, T., Chirala, S. S., and Wakil, S. J. (2005) Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knock-out mice. Proc. Natl. Acad. Sci. U.S.A. 102, 1384–1389 17. Essop, M. F., Camp, H. S., Choi, C. S., Sharma, S., Fryer, R. M., Reinhart, G. A., Guthrie, P. H., Bentebibel, A., Gu, Z., Shulman, G. I., Taegtmeyer, H., Wakil, S. J., and Abu-Elheiga, L. (2008) Reduced heart size and in- creased myocardial fuel substrate oxidation in ACC2 mutant mice. Am. J. Physiol. Heart Circ. Physiol. 295, H256–265 18. Livak, K. J., and Schmittgen, T. D. (2001) Analysis of relative gene expres- sion data using real-time quantitative PCR and the 2(- C T )) method. Methods 25, 402–408 19. Horton, J. D., Bashmakov, Y., Shimomura, I., and Shimano, H. (1998) Regulation of sterol regulatory element-binding proteins in livers of fasted and refed mice. Proc. Natl. Acad. Sci. U.S.A. 95 , 5987–5992 20. Kim, H. I., and Ahn, Y. H. (2004) Role of peroxisome proliferator-activated receptor- in the glucose-sensing apparatus of liver and -cells. Diabetes 53, S60-S65 21. Way, J. M., Harrington, W. W., Brown, K. K., Gottschalk, W. K., Sundseth, S. S., Mansfield, T. A., Ramachandran, R. K., Willson, T. M., and Kliewer, S. A. (2001) Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor activation has coordi- nate effects on gene expression in multiple insulin-sensitive tissues. Endo- crinology 142, 1269–1277 22. Walther, T. C., and Farese, R. V., Jr. (2009) The life of lipid droplets. Biochim. Biophys. Acta 1791, 459–466 23. Wiggins, D., and Gibbons, G. F. (1992) The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very low-density lipo- protein and its response to hormones and sulfonylureas. Biochem. J. 284, 457–462 24. Petersen, K. F., and Shulman, G. I. (2006) Etiology of insulin resistance. Am. J. Med. 119, S10–S16 25. Hoehn, K. L., Turner, N., Swarbrick, M. M., Wilks, D., Preston, E., Phua, Y., Joshi, H., Furler, S. M., Larance, M., Hegarty, B. D., Leslie, S. J., Pickford, R., Hoy, A. J., Kraegen, E. W., James, D. E., and Cooney, G. J. (2010) Acute or chronic up-regulation of mitochondrial fatty acid oxidation has no net effect on whole body energy expenditure or adiposity. Cell. Metab. 11, 70–76 26. Olson, D. P., Pulinilkunnil, T., Cline, G. W., Shulman, G. I., and Lowell, B. B. (2010) Gene knock-out of Acc2 has little effect on body weight, fat mass, or food intake. Proc. Natl. Acad. Sci. U.S.A. 107, 7598–7603 27. Gu, Y. G., Weitzberg, M., Clark, R. F., Xu, X., Li, Q., Zhang, T., Hansen, T. M., Liu, G., Xin, Z., Wang, X., Wang, R., McNally, T., Zinker, B. A., Frevert, E. U., Camp, H. S., Beutel, B. A., and Sham, H. L. (2006) Synthesis and structure-activity relationships of N -{3-[2-(4-alkoxyphenoxy-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxyl- ase 2 inhibitors. J. Med. Chem. 49, 3770–3773 28. Surwit, R. S., Kuhn, C. M., Cochrane, C., McCubbin, J. A., and Feinglos, M. N. (1988) Diet-induced type II diabetes in C57BL/6J mice. Diabetes 37, 1163–1167 29. Burcelin, R., Crivelli, V., Dacosta, A., Roy-Tirelli, A., and Thorens, B.
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