Drug to drug interactions penicillin g oral

•
Drug-to-Drug Interactions –
-
penicillin G, oral contraceptives, Digoxin

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Nursing Considerations for Patients
Receiving Tetracyclines
Nursing Considerations for Patients
Receiving Tetracyclines
•
Assess:
–
Known allergy to any tetracycline or to tartrazine
–
Physical examination
–
Skin for any rash or lesions
–
Culture and sensitivity tests
–
Respiratory status
–
Renal and liver function test reports

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Prototype Summary: Tetracycline
Prototype Summary: Tetracycline

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Question
Question
Tell whether the following statement is true or false.
Sulfonamides should not be given with thiazide diuretics
because of a cross sensitivity of the drugs.

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Answer
Answer
True
Rationale: Drug-to-Drug Interactions: Cross sensitivity with
thiazide diuretics; Sulfonareas

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Antimycobacterial
Antimycobacterial
•
Contain pathogens causing TB and leprosy
•
Most common medications-
–
Rifabutin ( Mycobutin ), isoniazid (generic), rifampin
( Rifadin ), pyrazinamide (generic), ethambutol,
( Myambutol ), streptomycin (generic), and rifapentine,
( Priftin )

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Antimycobacterial Cont.
Antimycobacterial Cont.
•
Action-
–
Act on the DNA of the bacteria leading to lack of growth
and eventual bacterial death for TB and Leprosy
•
Indications-
Treatment of TB and Leprosy
•
Pharmacokinetics-
–
Well absorbed from the GI tract
–
Metabolized in the liver, excreted in the urine, cross the
placenta and enter breast

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Antimycobacterial Cont.
Antimycobacterial Cont.
•
Contraindications
–
Allergy, renal or hepatic failure, CNS dysfunction and
pregnancy
•
Adverse Effects
–
CNS effects and GI irritation
•
Drug-to-Drug Interactions
–
Rifampin and INH can cause liver toxicity

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Nursing Considerations for Patients
Receiving Antimycobacterials
Nursing Considerations for Patients
Receiving Antimycobacterials
•
Assess:
–
Known allergy to any antimycobacterial drug
–
History of renal or hepatic disease and CNS dysfunction
–
Physical examination
–
Skin for any rash or lesions
–
Culture and sensitivity testing
–
Respiratory status and evaluate renal and hepatic function
tests

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Prototype Summary: Isoniazid
Prototype Summary: Isoniazid

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Other Antibiotics
Other Antibiotics
•
Ketolides, Lincosamides, Lipoglycopeptides,
Macrolides, Oxazolidinones, Monobactam ,
–
Antibiotics that do not fit into the large antibiotic classes
–
Most common medications-
•
telithromycin ( Ketek ), telithromycin, Clindamycin
(Cleocin) televancin ( Vibativ ), dalbavancin ( Dalvance ),
and oritavancin ( Orbactiv ), azithromycin (