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Clozapine to find the one that would work for her since it was a medication that has worked for her in the past. During the last few weeks, she has been complaining of chest discomfort. Each time she reports of the discomfort, the staff does an EKG on her. For the last few days, she states that the pain is becoming worse. Pharmacodynamics“Clozapine is a medication thatbinds loosely and transiently to dopamine D2 receptors but the implications of these binding activities are unclear. Clozapine also binds to D1, D3, and D5 receptors, and has a high affinity for the D4 receptor” (McEvoy, 2018) . Some research shows this to include the limbic system.
Pharmacokinetics“Clozapineis quickly absorbed. First-pass metabolism reduces its bioavailability to 60 to 70 percent of the administered dose; food has little effect on the bioavailability of clozapine. The elimination half-life of clozapine averages approximately 14 hours under steady state conditions,but there is substantial variability across individuals depending on that individuals own metabolism and under lying factors” (McEvoy, 2018).