Prevent water evaporation and promote drug penetration marginally However

Prevent water evaporation and promote drug

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Prevent water evaporation and promote drug penetration marginally. However, direct hydration would significantly increase the permeation of the drug compared to occlusion Temperature Temperature causes significant increase in drug penetration 1) passive diffusion, which is dependent on temp, 2) body temp increase causes increased blood flow to capillaries Rubbing Increases the amount of drug absorbed Causes temporary increase of the fluidity of the skin Duration of Application Longer the period of application - greater is the absorption Amount of drug absorption via passive diffusion increases with time Frequency of Application Multiple dosing (application) increases absorption Multiple application could increase the concentration gradient
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