Table 2 intra group comparison of plaque index using

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Table 2: Intra-group comparison of plaque index using repeated measures of analysis of variance Group ( n =30) PI (mean±SD) Baseline 4 weeks 12 weeks P Group A (SRP only) 2.33±0.25 1.71±0.38* 1.82±0.31* 0.000 Group B (SRP + HA gel) 2.41±0.19 1.61±0.36* 1.81±0.44* 0.000 *Values highly significant ( P <0.001) as compared to the baseline levels using multiple comparison test. PI – Plaque index; SD – Standard deviation; SRP – Scaling and root planing; HA – Hyaluronic acid Relative attachment level There was no statistical difference found at baseline between the test and the control group. However, there was a significant reduction in the RALs in test group as compared to the control group at both, 4 weeks ( P = 0.00) and 12 weeks ( P = 0.00) recall as shown in Table 7 and Graph 7. Comparison at different time Graph 2: Intra-group comparison of plaque index Graph 4: Intra-group comparison of gingival index intervals during follow-up showed a statistically significant reduction in the RALs at each follow-up as compared to baseline. However, no statistically significant reduction was seen between the 4 weeks and the 12 weeks follow-up. These findings were true for both the test and the control group [Table 8 and Graph 8]. DISCUSSION Periodontal diseases are plaque-associated infections initiated by the accumulation and maturation of pathogenic biofilms of the surface of the teeth and oral mucosal surfaces. Periodontitis appears in a generalized form but more often appears in local areas in a patient’s mouth or is reduced to localized areas after Phase I treatment. [20] Nonsurgical therapy remains the cornerstone of periodontal treatment. [21] However, the ability of the clinician to gain access to deep pockets, during SRP, often results in a substantial variation in its effectiveness. [20] To overcome these limitations, LDD systems were developed. [6] A number of studies have reported a variety of LDD systems as adjunct to SRP. However, the outcomes obtained from these results have been questioned for their clinical superiority as compared to the conventional debridement and have emphasized on the need for further research for the same. [22] HA has been attributed a protective role in inflammatory damage. Hyaluronan in its various forms, shows bacteriostatic, fungistatic, anti-inflammatory, anti-edematous, osteoinductive, and pro-angiogenetic properties, thereby promoting wound healing in a variety of tissues. [14] Table 1: Inter-group comparison of plaque index using Student’s t -test Group ( n =30) PI (mean±SD) Group A (SRP only) Group B (SRP + HA gel) P Baseline 2.33±0.25 2.41±0.19 0.073 1 month 1.71±0.38 1.61±0.36 0.752 3 months 1.82±0.31 1.81±0.44 0.105 Test applied Student’s t -test. Significance level P <0.05. PI – Plaque index; SD – Standard deviation; SRP – Scaling and root planing; HA – Hyaluronic acid [Downloaded free from on Friday, September 15, 2017, IP:]
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Shah, et al .: Hyaluronan as local drug delivery Journal of Indian Society of Periodontology 5 Healing of periodontal wound includes a series of highly reproducible and rigidly controlled biologic events which includes inflammation, granulation tissue formation, epithelium formation, and tissue remodeling. Hyaluronan
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  • Fall '19
  • Statistical significance, SRP, Periodontitis, Hyaluronan

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