Human Physiology From Cells to Systems 8 th ed Belmont CA BrooksCole Cengage

Human physiology from cells to systems 8 th ed

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Human Physiology: From Cells to Systems. 8thed. Belmont CA: Brooks/Cole, Cengage Learning, 2013.Myosin head arrangement: Smooth vs. Skeletal
Smooth muscle activity is determined by the phosphorylation status of regulatory myosin light chains (MLCs)Phosphorylation of MLCs initiates cross-bridge cyclingCa2+/calmodulin activates MLCKPKA inhibits MLCKPKG activates MLCP PKC inhibits MLCP5Sherwood L. Human Physiology: From Cells to Systems. 8thed. Belmont CA: Brooks/Cole, Cengage Learning, 2013. p 296.MLCK/MLCP activity ratio
Gastrointestinal smooth muscle: myogenic activity is driven by interstitial cells of CajalInterstitial cells of Cajal (ICC) generate slow-wave potentials6Les-Green et al. (2011) Frontiers in Physiology. 2(29). Image: Dr. Lei Sha, Mayo Clinic.
Slow-wave potentials spread from ICCs to neighboring gastrointestinal smooth muscle cells through gap junctions7AP depolarization: L-type V-gated Ca2+channelsAP repolarization: Delayed Rectifier V-gated K+ channelsSherwood L. Human Physiology: From Cells to Systems. 8thed. Belmont CA: Brooks/Cole, Cengage Learning, 2013. p 298.

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