Myosin head is sufficient for motor activity

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Myosin head is sufficient for motor activity
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Figure 16-57 Molecular Biology of the Cell (© Garland Science 2008) * * *only in plants 1 only in vertebrates 1 Myosin superfamily members
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Two-headed unconventional myosin – Myosin V – vesicle transport Pigment granules (melanosomes) are transported into pigment cells by myosin Va. Melanosomes are then transferred to hair follicles where they become incorporated into a developing hair Mice lacking myosin Va – unable to transfer melanosomes into hair follicles – resulting in coat with lighter color Humans lacking myosin Va or Rab27a – defects in vesicle transport – Griscelli Snydrome – partial albinism
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Unconventional myosin -- Myosin VIIa Mutation in this gene causes – Usher 1B syndrome – which is characterized by both deafness and blindness Hair cells of inner ear of normal mice Myosin VIIa mutant mice Myosin VI – organelle transporter – movement in reverse direction toward minus end of actin filament
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Myosin mode of action Figure 16-61 Molecular Biology of the Cell (© Garland Science 2008) Rigor configuration Attached Released Cocked Force-generating Attached
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Myosin mode of action
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Microtubules - Provide support for internal structure and position of organelles like the Golgi and ER.
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