30 patients diagnosed with uws underwent fmri

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30 patients diagnosed with UWS underwent fMRI examination. 15 healthy participants.
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Structural brain Atrophy (0 none - 4 very severe). M=3.1 (.09) Coma Recovery Scale M=5.4 (1.4)
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Experimental procedure Alternating blocks of noxious stimulation and baseline. 60 seconds each (60 noxious stimuli [1/sec, electrical stimulus lasting 200 ms on left index finger] or 60-sec rest). Electrical stimulation rated as 3.9 (1.28) out of 10 in painfulness and 7.81 (.91) out of 10 on unpleasantness.
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Healthy controls Group vs. individuals Sensory regions Affective regions Correlation between BOLD in affective regions with age (.7)
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UWS patients As can be seen in Table 4 and Figure 2, 15 UWS patients (50%) exhibited significant activations in the sensory part of the pain matrix and/or the cerebellum, nine (30%) UWS patients exhibited significant activations in the affective part of the pain matrix (ACC and/or anterior insula), and in eight (26.7%) UWS patients both sensory (including cerebellum) and affective components were activated. Activation in the higher order structures was found in 15 (50%) UWS patients and lower order structures were activated in four patients (13.3 %)”
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UWS patients Trend towards sub(acute) patients compared with more chronic patients showing greater activation in sensory networks. Confounds in interpretation?
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