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Unformatted text preview: Kinase domains are highly conserved; differ in their extracellular domains • When ligand binds, the ligand-receptor complex internalizes and is then transported to the cell body by axonal transport Superfamilies of Growth Factors • Neurokines: related to the cytokine family but restricted to nervous system; receptors are multisubunit complexes (gp130 + 1 additional); transduces signals via JAK family of kinases • Fibroblast Growth Factors : first identified because they stimulated the proliferation of fibroblasts; now known to regulate neuronal and glial proliferation and be the major mitogenic species in nervous system; 4 genes/receptors for FGFs but multiple splice variants so a large variety of targets; distinct subfamily of RTKs • Transforming growth factor : larger superfamily with 24 members arranged into subfamilies; GDNF signals through a dimerized RTK • Epidermal Growth Factors : EGF (stem cells) – Neuregulins (arise from alternative splicing of a single gene); ~12 isoforms; secreted proteins with a region homologous with EGF; bind to a family of RTKs called erbBs...
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- Spring '13
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