b.Analyze the steps of the arachidonic acid pathway and describe the implications for treatment of inflammation. 5.Analyze disorders which affect immune function. Etiology Clinical Manifestations Pathophysiology Systemic Lupus Erythemato sus (autoimmu ne) Diverse maternal autoantibodies induce anomalies (ie: congential heart defects) in the fetus or cause pregnancy loss -Maternal alloantibody transported across placenta to fetal circulation -Disease process develops slowly, up to 10 years Chronic, multisystem inflammatory disease -Large antibodies produced nucleic acids (*DNA, RNA), erythrocytes, coag proteins, phospholipids, lymphocytes, platelets - DNA in circulation from cellular damage in response to trauma, drugs, infections that are usually removed by the liver > for deposition in the kidneys -*NO CURE, tx symptoms -Nsaids (ASA, ibuprofen) to Complement participation -Neutrophils involved -IgG, IgM -Type II (tissue specific hypersensitivity) -Can cause inflammatory lesions -More often in women -Flares up from environmental
-Difficult to diagnose (4/11 to be diagnosed on list)
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- Fall '15