PHRM 514 - Asthma - Fall 2012 (1)

What was the estimated cost associated with asthma in

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What was the estimated cost associated with asthma in the U.S. in 2007? 1. $15 million 2. $56 million 3. $5 billion 4. $15 billion 5. $56 billion Vital Signs Asthma in the U.S.. Centers for Disease Control and Prevention. Updated May 3, 2011. Accessed October 16, 2011.
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Social and Economic Burden in the U.S. Ambulatory care visits (2007) 17 million people Hospital discharges (2009) 479,000 Average hospital length of stay (2009) 3.4 days n About 53% of those with asthma had an asthma attack in 2008 n About 3,388 deaths/year (2009 data)80 to 90% preventable Fast Stats Asthma. Centers for Disease Control and Prevention. . Updated June 19, 2012. Accessed October 10, 2012. Kelly HW, Sorkness CA. Asthma. In: DiPiro JT, Talbert RL, Yee GC, et al., eds. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:439-448.
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Pathophysiology Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. National Institutes of Health, National Heart, Lung, and Blood Institute, National Asthma Education and Prevention Program. asthgdln.pdf. Published August 28, 2007. Accessed October 16, 2011. Bronchoconstriction Allergen or irritant induced Airway edema Airway hyper- responsiveness Airway remodeling Airway cells Inflammatory mediators
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Airway Obstruction n Recurrent n Caused by ¡ Bronchoconstriction ¡ Airway edema ¡ Airway hyperreponsiveness ¡ Airway remodeling Kelly HW, Sorkness CA. Asthma. In: DiPiro JT, Talbert RL, Yee GC, et al., eds. Pharmacotherapy a pathophysiologic approach. 8th ed. New York: McGraw Hill Medical; 2011:439-448. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma. . Updated 2011. Accessed October 10, 2012. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. National Institutes of Health, National Heart, Lung, and Blood Institute, National Asthma Education and Prevention Program. . Published August 28, 2007. Accessed October 16, 2011.
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Bronchoconstriction n Bronchial smooth muscle contraction that quickly narrows the airway n Bronchoconstriction occurs to narrow airways in response to varying stimuli including allergens/antigens or irritants ¡ Allergic reaction ¡ Aspirin and NSAIDS ¡ Exercise ¡ Cold air ¡ Stress n Airway narrowing and airflow interference lead to clinical symptoms Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. National Institutes of Health, National Heart, Lung, and Blood Institute, National Asthma Education and Prevention Program. asthgdln.pdf. Published August 28, 2007. Accessed October 16, 2011.
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Allergen Induced Bronchoconstriction: Early Phase Allergic Reaction 1.
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