Neutrophils Aka Polymorphonuclear l of circulating WBCs Pale

Neutrophils aka polymorphonuclear l of circulating

This preview shows page 5 - 9 out of 10 pages.

Neutrophils: Aka Polymorphonuclear leukocytes 50-70% of circulating WBCs Pale cytoplasm granules with o Lysosomal enxymes o Bactericides (hydrogen peroxide & superoxide) Action: o Very active, first to kill bacteria o Digests and engulfs pathogens Degranulation: removes granules from cytoplasm Defensins (peptides from lysosomes): attacks pathogen membranes o Release prostaglandins: produces heat, swelling, inflammation/pain o Releases leukotrienes: released in response to allergen exposure o Forms pus Eosinophils Aka acidophils 2-4% circulating WBCs Attacks large parasites
Image of page 5
Excretes toxic compounds such as nitric oxide and cytotoxic enzymes Sensitive to allergens Releases histamine * Control inflammation with enzymes that counteract inflammatory effects of neutrophils and mast cells Basophils Less than 1% of circulating WBCs Small Accumulate in damaged tissues Releases histamine, dilates blood vessels Releases heparin* prevents blood clots Monocytes 2-8% circulating WBCs Large & spherical Enters peripheral tissues and becomes macrophages Engulfs large particles and pathogen Secretes substances that attract immune system cells and fibrocytes to injured area Lymphocytes: 20-30% circulating WBCs Larger than RBCs Migrate in/out of blood Mostly in connective tissues & lymphoid organs Part of body’s specific defense system Three Classes: o T-Cells Cell mediated immunity Attacks foreign cells directly o B cells Humoral immunity (anitbody mediated) Differentiate into plasma cells Synthesize antibodies o Natural killer (NK) cells Detect and destroy abnormal tissue cells (cancers) Production: Originate from hemacytoblasts
Image of page 6
o Produces myeloid and lymphoid cells o Myeloid: Differentiate into progenitor cells, which produce all WBCs except lymphocytes DO NOT produce T-Cells, B- Cells or NK Cells. o Lymphoid: Lymphopoiesis: the production of lymphocytes Development Bone marrow except monocytes o Monocytes: macrophages of peripheral tissues Regulation: CSFs: colony stimulating factors o Regulates blood cell populations o 1. M-CSF stimulates monocyte production o 2. G-CSF stimulates granulocyte (neutrophils, eosinophils, and basophils) production o 3. GM-CSF stimulates granulocyte and monocyte production o 4. Multi-CSF accelerates production of granulocytes, monocytes, platelets, and RBCs o Platelets Cell fragments involved in clotting Non mammalian vertebrates have thrombocytes (nucleated cells) Circulates for 9-12 days Removed by spleen 2/3 reserved for emergencies Functions: Releases important clotting chemicals Temporarily patches damaged blood vessel walls Actively contracts tissue after clot formation Production: Aka thrombocytopoeisis o Occurs in bone marrow Megakarocytes o Giant cells in bone marrow
Image of page 7
o Manufactures platelet into cytoplasm Hormonal controls o Thrombopoietin (TPO) o Interleukin-6 (IL-6) o Multi-CSF
Image of page 8
Image of page 9

You've reached the end of your free preview.

Want to read all 10 pages?

  • Spring '10
  • Dr.WalliedSamurai
  • Physiology, Anatomy, cells, Magidah Alaudi, Bone marrow

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes