production in old versus young tissue contributes to aging Yeast NDI1 serves

Production in old versus young tissue contributes to

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production in old versus young tissue contributes to aging Yeast NDI1 serves similar role to Complex I in ETC Adding NDI1 to Complex I deficient flies rescues ETC activity Adding NDI1 to WT flies Increases Complex I activity Increases ATP production Increases CO2 production (indicating greater respiration rate) Q: does adding NDI1 to WT flies improve lifespan? GAL4+Regulator/UAS system Requires addition of RU486 for transactivator to bind to UAS
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GAL4 binding sequence and induce transcription of target gene Found that expression of NDI1 in neurons and intestines of flies improves lifespan Q: does increasing expression of mitochondrial genes improve lifespan? PGC-1 family of co-transcription factors related to mitochondrial gene expression Over-expression of PGC-1 leads to increased Complex I and Complex V prevalence increased O2 consumption (increased respiration) Found that targeted over-expression in the intestinal cells improve lifespan Conclusion Mitochondrial decline seems to be major contributing factor in aging Preventing mitochondrial decline by up-regulating ETC-related enzymes reduces mitochondrial decline and improves lifespan
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  • Spring '18
  • David Walker

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