Acquisition of different cell fates Asymmetrical Distribution YapTaz Amot Table

Acquisition of different cell fates asymmetrical

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--- Acquisition of different cell fates Asymmetrical Distribution Yap/Taz Amot
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Table 5.1 Some stem cell niches of adult humans
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Figure 5.8 Stem cell niche in Drosophila testes Stem cell niche in Drosophila testes – Hub cells Paracrine factors : Unpaired in the JAK/STAT pathway More Unpaired Less Unpaired Asymmetrical division Stem cell Progenitor cell Differentiation
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Figure 5.9 Drosophila ovarian stem cell niche TGF- b maintains stemness of GSC by suppressing bam expression. Asymmetrical division Germarium bam differentiation
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Figure 5.12 Young blood can rejuvenate an old mouse through parabiosis. More vasculature More vasculature and progenitor cells
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Figure 5.18 Mesenchymal stem cell differentiation is influenced by the elasticity of the matrices upon which the cells sit Remarkable mesenchymal (bone marrow-derived) stem cells (MSC) Substrate-dependent differentiation MSCs in bone marrow, fat, muscle, Thymus, dental pulp and umbilical cord TGF- b & PDGF MSC differentiation
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Figure 5.20 Major sources of pluripotent stem cells from the early embryo Pluripotency: ability to generate all 220 cell types of the adult mammalian body
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Figure 5.21 Inducing stem cell differentiation from ESCs Guiding stem cells to certain tissue types Paracrine factors
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Figure 5.22 Human ESCs cultured in confined micropatterned discs demonstrate a pattern of differential gene expression similar to that seen in the early embryo Guiding stem cells to certain tissue types Physical constraints 3D substrates Adhesive substrates
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ICM Ectoderm Mesoderm Endoderm
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Figure P3.11 Pluripotent ES cells derived from the early embryo can generate all the types of somatic cells Stem cells can be induced from differentiated adult cells --- induced pluripotent stem cells Disease models-pathology Disease models-drug discovery Gene therapy Organ or tissue transplant
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Figure 5.23 Lung epithelium derived from mouse iPS cells Lung epithelial cells from iPSC for cystic fibrosis study Red: Nxk2.1, Green: tubulin (cilia)
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