Surrounding the embryo is removed and the embryonic

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surrounding the embryo is removed and the embryonic cells in this fluid are examined for genetic abnormalities. i. If you were to look at the expression of XIST gene in the cells of a fetus with Klinfelter’s syndrome, how many X chromosomes do you expect to see strongly expressing XIST RNA? How about in cells of a normal boy and girl fetuses? ii. Which of the following techniques can you use to visualize XIST RNA expression? A. Southern blot B. Chromosomal painting C. RNA in situ hybridization
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D. Western blot E. FACS 9. List and briefly describe the steps leading to inactivation of chromosome X. 10. Give two examples of a chromatin modification that leads to inactivation of gene expression (be specific, indicate which histone and which amino acid is involved). Provide an example of a chromatin modification that is associated with active gene transcription. 11. Explain why Kleinfelter’s syndrome has a relatively mild phenotype, despite the fact that it involves an abnormal dosage of a large chromosome. Why does it have a phenotype at all?
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