B cell differentiatio n lymphocyte differenti ation

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B-cell differentiatio n lymphocyte differenti ation lymphocyte B-cell GO CL is_a cell differentiation blood cell B-cell activati on Relations to Other Ontologies
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[Term] id: GO:0030183 name: B-cell differentiation is_a: GO:0042113 ! B-cell activation is_a: GO:0030098 ! lymphocyte differentiation intersection_of: is_a GO:0030154 ! cell differentiation intersection_of: has_participant CL:0000236 ! B-cell [Term] id: CL:0000236 name: B-cell is_a: CL:0000542 ! lymphocyte develops_from: CL:0000231 ! B-lymphoblast Augmented GO CELL Ontology
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There are many less than perfect ontologies
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Use the power of combination and collaboration Ontologies are like telephones: they are valuable only to the degree that they are used and networked with other ontologies But to work telephones must be connected Like telephones, most ontologies were broken when the technology was first being developed
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The OBO-Foundry is: foun·dry An establishment where metal is melted and poured into molds OBO-foun·dry An establishment where scientific theory is formalized and represented in ontologies
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To create the conditions for a step-by-step evolution towards robust gold standard reference ontologies in the biomedical domain. To introduce some of the features of scientific peer review into biomedical ontology development. obofoundry.org
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OBO Foundry A subset of OBO ontologies whose developers agree in advance to accept a common set of principles designed to assure intelligibility to biologist curators, annotators, users formal robustness stability compatibility interoperability support for logic-based reasoning The OBO Foundry The OBO Foundry
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RELATION TO TIME GRANULARITY CONTINUANT OCCURRENT INDEPENDENT DEPENDENT ORGAN AND ORGANISM Organism (NCBI Taxonomy? ) Anatomica l Entity (FMA, CARO) Organ Function (FMP, CPRO) Phenotypic Quality (PaTO) Biological Process (GO) CELL AND CELLULAR COMPONENT Cell (CL) Cellular Component (FMA, GO) Cellular Function (GO) MOLECULE Molecule (ChEBI, SO, RnaO, PrO) Molecular Function (GO) Molecular Process (GO) Building out from the original GO December 1 st & 2 nd
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he OBO Foundry he OBO Foundry ttp://obofoundry.org/ CRITERIA The ontology is OPEN and available to be used by all. The ontology is in, or can be instantiated in, a COMMON FORMAL LANGUAGE . The developers of the ontology agree in advance to COLLABORATE with developers of other OBO Foundry ontology where domains overlap.
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CRITERIA UPDATE: The developers of each ontology commit to its maintenance in light of scientific advance, and to soliciting community feedback for its improvement. ORTHOGONALITY: They commit to working with other Foundry members to ensure that, for any particular domain, there is community convergence on a single controlled vocabulary.
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