Furthermore microRNAs miR 15a p 0001 and miR 16 p 5 0016 were more elevated in

Furthermore micrornas mir 15a p 0001 and mir 16 p 5

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elevated in powerlifters. Furthermore, microRNAs miR-15a ( p , 0.001) and miR-16 ( p 5 0.016) were more elevated in power- lifters, which both have been shown to have an inhibition effect on the formation of new blood vessels through vascular endo- thelial growth factor ( p 5 0.064), which was almost more abundant in powerlifters. As well, microRNAs miR-451a ( p 5 0.017) and miR-30b ( p 5 0.013) expression were more elevated Figure 1. Flow diagram of the search strategy and article selection process. Classic Powerlifting Performance (2019) 33:7S S196 Copyright © 2019 National Strength and Conditioning Association. Unauthorized reproduction of this article is prohibited.
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in powerlifters, whereas Cyclin D1 ( p 5 0.198), miR-145 ( p 5 0.730), and SPRED-1 ( p 5 0.083) showed no difference between groups, whereas miR-126 ( p , 0.001) and cyclin D2 ( p 5 0.019) had lower expression in powerlifters compared with controls. A discriminant analysis revealed that the combination of the 5 microRNAs, miR-126, miR-3b, miR-16, miR-23a, and miR-15a, classified correctly all participants into their respective group (powerlifters and control) (7). Procedures Classification of the retained articles was performed by regrouping them by topics after screening the text. The weight of the search was placed on descriptive and quantitative results that were related to performance in classic powerlifting. In addition, several studies have been directed on both sexes (male and female) and on different levels of athletes. Therefore, the sex and the level of the athletes are mentioned when summarizing study results. Titles, abstracts, and full texts coming from studies gathered through the systematic and the manual search were screened in- dependently by the 2 reviewers to identify studies that potentially met the inclusion criteria. Any disagreement between the 2 reviewers over the eligibility of particular studies would have been resolved through discussion with a third reviewer. The authors did take time to contact corresponding authors from 16 articles retained after abstract screening for missing in- formation as the authors did not specify in their methodology if their study was conducted on classic powerlifting or drug-tested powerlifters. The correspondence authors were contacted a min- imum of 2 times by e-mail and once through the researchgate website. All other retractable authors were contacted at least once by e-mail and once through researchgate. Results A total of 230 titles came out of the initial database search. Of those 230, 80 were removed because they were duplicates and 44 were removed because they were not published in English. Therefore, 106 titles were left for screening. Of those 106 titles, 35 were discarded because they did not match the eligibility criteria. Consequently, 71 abstracts were read and another 19 studies were discarded, leaving 52 articles for detailed reading. Of the 52 articles, 5 were discarded because of poor quality, 1 was dis- carded because it was not related to performance, 1 was discarded because it was not conducted on powerlifters, 20 were discarded because they were not conducted on classic powerlifting, 6 were discarded because they were not conducted on drug-tested ath-
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