Gleason Score 7 Can be considered a moderately well differentiated or poorly

Gleason score 7 can be considered a moderately well

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Gleason Score 7Can be considered a moderately well differentiated or poorly differentiated cancerGlands are incompletely formedGleason Score 8 to 10 (most aggressive and most dangerous)Poorly differentiatedSingle cells have broken away and may be found within vascular lumen (loses adhesion)Cancer cells can behave in unpredictable manner Prostate Cancer Grade and Stage are used Together to Determine Prognosis:Treatments and Statistics:What can be done? (What stage are you in and how active is the cancer)oActive surveillance (come back yearly for check ups)oSurgeryoRadiation therapyoHormone therapyoChemotherapyoImmunotherapyWhat is considered?oYour ageoGleason score (grade) of the tumoroStage of prostate canceroYour symptomsThe TNM staging scheme is used for prostate cancer,however some clinicians use a different methodTNM is gained via fully body imaging—this information is combined with Gleason Grading to generate a prognosis and a treatment regimeAnything higher than a Gleason score of 4 will push you to different stages oStage 4: T4—very severe (might not have lymph node/metastasis)
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oYour general health (comorbidity: presence of two or more chronic diseases present in the patient)Diagnosis rate=1 in 6, death rate=1 in 35oMost men are over 70 at time of diagnosis and die of other causesoOverall 5-year survival rate=99%oFor localized prostate cancer 5-year survival=100%oFor metastatic prostate cancer, 5-year survival=33%oLong term survival:The relative 10-year survival rate is 91%The relative 15-year survival rate is 76%Surgery:The entire prostate can be removed in several ways:oRadical retropublic prostatectomy (trying to go through the body wall)oLaparoscopic prostatectomy (small tiny cuts in the abdomen)oRobotic prostectomy (robots can be very tiny—remotely trying to find the prostate and remove as much as possible)oRadical perineal prostatectomy Other surgery options for treating prostate cancer or relieving its symptoms are:oCyrosurgery (insert the probe and freeze the surgery)oHeating: trying to heat up the prostate to destroy the tissueoTURP (transurethral resection of the prostate)—they can surgically start snipping away at the prostate gland—has the least risk
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